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Research
B cell epitope mapping: The journey to better vaccines and therapeutic antibodiesB-cell epitope mapping is an approach that can identify and characterise specific antigen binding sites of B-cell receptors and secreted antibodies. The ability to determine the antigenic clusters of amino acids bound by B-cell clones provides unprecedented detail that will aid in developing novel and effective vaccine targets and therapeutic antibodies for various diseases.
Research
Transcriptional rewiring in CD8+ T cells: implications for CAR-T cell therapy against solid tumoursT cells engineered to express chimeric-antigen receptors (CAR-T cells) can effectively control relapsed and refractory haematological malignancies in the clinic. However, the successes of CAR-T cell therapy have not been recapitulated in solid tumours due to a range of barriers such as immunosuppression, poor infiltration, and tumour heterogeneity.
Research
Mesothelioma survival prediction based on a six-gene transcriptomic signatureMesothelioma is a lethal cancer. Despite promising outcomes associated with immunotherapy, durable responses remain restricted to a minority of patients, highlighting the need for improved strategies that better predict outcome. Here, we described the development of a mesothelioma-specific gene signature that accurately predicts survival.
Research
Effect of a campaign with oral polio vaccine on general health: A cluster-randomised trial in rural Guinea-BissauObjectives: To investigate in a cluster-randomised trial whether a campaign with oral polio vaccine (C-OPV) reduced mortality and morbidity.
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The application of environmental health assessment strategies to detect Streptococcus pyogenes in Kimberley school classroomsChildren spend almost one-third of their waking hours at school. Streptococcus pyogenes (Strep A) is a common childhood bacterial infection that can progress to causing serious disease. We aimed to detect Strep A in classrooms by using environmental settle plates and swabbing of high-touch surfaces in two remote schools in the Kimberley, Western Australia.
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Whole genome sequencing reveals extensive community-level transmission of group A Streptococcus in remote communitiesThere was evidence of extensive transmission of group A Streptococcus both within households and across the community
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Association of gestational age and growth measures at birth with infection-related admissions to hospital throughout childhoodChildren who were born with reduced gestational age, birthweight, and birth length have persistently increased rates of infection-related admissions to hospital until age 18 years
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Conceptualizing a quality of life framework for girls with Rett syndrome using qualitative methodsExisting quality of life scales for children in the general population or with other disabilities did not capture the QOL of children with Rett syndrome
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Maternal Work–Family Conflict and Psychological Distress: Reciprocal Relationships Over 8 YearsEmployed mothers may benefit from policies and workplace practices that promote maternal well-being and reduce conflicts between employment and raising children
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Multiple breath washout cannot be used for tidal breath parameter analysis in infantsThere are differences in tidal breathing parameters during multiple breath washout testing with SF6 gas mixture in infants
News & Events
Suicide prevention guidelines to drive better services for LGBTQA+ young peopleResearchers have developed Australia’s first comprehensive guidelines for clinical and community services supporting LGBTQA+ youth.
News & Events
Paediatric anaesthetist named a WA Young Tall PoppyA leading paediatric anaesthetist and researcher focused on making anaesthesia safer and more comfortable for children has been named a 2022 Western Australian Young Tall Poppy.
News & Events
Sophisticated modelling shows WA’s Omicron outbreak still has months to runWestern Australia’s Omicron outbreak is far from over, with new modelling showing the number of total infections is only at its half-way point.
News & Events
Telethon supports vital child health research projectsThe generous support of West Australians through Channel 7’s Telethon Trust will help support crucial child health research at The Kids Research Institute Australia in 2022.
News & Events
Call for urgent funding boost for RHD in AustraliaThere are calls for a significant and urgent injection of $40 million in funding to tackle Rheumatic Heart Disease (RHD) following Monday night’s Four Corners episode.
News & Events
Federal politicians urged to adopt transport priorities that keep kids happy, healthy and safeThe Kids Research Institute Australia has backed a series of transport priorities to keep children safer on the roads, boost physical activity levels, and save the economy billions of dollars.
News & Events
THINKING BIG @The Kids Research Institute AustraliaWe want to hear from people across the WA community - about the big issues and concerns facing our children, young people, and their families. Share your voice and views to help guide our research for happy, healthy kids.
News & Events
Study to use eye masks and earplugs to teach preterm babies the rhythm of lifeResearchers will fit nearly 500 preterm babies with tiny eye masks and earplugs for the study.
News & Events
The Kids respiratory, anaesthesia and mental health researchers secure vital fundingThe Kids Research Institute Australia researchers have been awarded $5.3 million in prestigious Investigator Grants from the National Health and Medical Research Council