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News & Events
Introducing Illuminate PitchFestAt The Kids our greatest asset is our people. We are strongly invested in the future of child medical research welcoming, nurturing, and encouraging the best and most innovative Australian and international researchers.
News & Events
Making a splash for researchWe were honoured to hear the story of the incredible Darcey Brooks who is tackling the Rottnest Channel Swim this Saturday to help raise money for research here at The Kids.
Research
The critical role of the bone marrow stromal microenvironment for the development of drug screening platforms in leukemiaExtensive research over the past 50 years has resulted in significant improvements in survival for patients diagnosed with leukemia. Despite this, a subgroup of patients harboring high-risk genetic alterations still suffer from poor outcomes. There is a desperate need for new treatments to improve survival, yet consistent failure exists in the translation of in vitro drug development to clinical application.
Research
FDA-approved disulfiram as a novel treatment for aggressive leukemiaAcute leukemia continues to be a major cause of death from disease worldwide and current chemotherapeutic agents are associated with significant morbidity in survivors. While better and safer treatments for acute leukemia are urgently needed, standard drug development pipelines are lengthy and drug repurposing therefore provides a promising approach.
Research
Systematic In Vitro Evaluation of a Library of Approved and Pharmacologically Active Compounds for the Identification of Novel Candidate Drugs for KMT2A-Rearranged LeukemiaPatients whose leukemias harbor a rearrangement of the Mixed Lineage Leukemia (MLL/KMT2A) gene have a poor prognosis, especially when the disease strikes in infants. The poor clinical outcome linked to this aggressive disease and the detrimental treatment side-effects, particularly in children, warrant the urgent development of more effective and cancer-selective therapeutics.
The main aim of our Leukaemia Translational Research Team is to test innovative therapeutic approaches, with a focus on clinical translation of this knowledge, to improve the outcomes of children suffering from leukaemia.
Research
Infection and VaccinesListed are The Kids Research Institute Australia research teams involved in our Infection and Vaccines Program. This program sits under the Early Environment research theme.
People
Associate Professor W. Joost LesterhuisProgram Head, Cancer; Chronic and Severe Diseases RFA Deputy Head
Research
Cancer ProgramListed are all The Kids Research Institute Australia research teams involved in our Cancer Program. This program sits under the Chronic and Severe Diseases research theme.