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Research
Predicting immune protection against outcomes of infectious disease from population-level effectiveness data with application to COVID-19Quantifying the extent to which previous infections and vaccinations confer protection against future infection or disease outcomes is critical to managing the transmission and consequences of infectious diseases. We present a general statistical model for predicting the strength of protection conferred by different immunising exposures (numbers, types, and strains of both vaccines and infections), against multiple outcomes of interest, whilst accounting for immune waning.
Research
Polyamine depletion limits progression of acute leukaemiaCancer cells are addicted to polyamines, polycations essential for cellular function. While dual targeting of cellular polyamine biosynthesis and polyamine uptake is under clinical investigation in solid cancers, preclinical and clinical studies into its potential in haematological malignancies are lacking. Here we investigated the preclinical efficacy of polyamine depletion in acute leukaemia.
Research
Experiences of exercise services for individuals with severe mental illness: A qualitative approachRegular exercise can be beneficial for people living with a severe mental illness. By better understanding the perspectives and challenges of adults with severe mental illness who are engaged in exercise, we can enhance the design and implementation of exercise programs to better support their mental health and recovery.
Research
Patient and carer priorities for research and clinical care of children with Down syndromeDown syndrome, the most common genetic disorder, is caused by the presence of all or part of a third copy of chromosome 21. We identified the top 10 patient and carer research priorities for children with Down syndrome.
Research
Moorditj Marp (Strong Skin) Evaluation and development of culturally relevant healthy skin storybooksCo-designed and in collaboration with community members, the impacts of this project will directly benefit families by building awareness, empowering decision-making, and improving confidence around the recognition and management of skin conditions for Aboriginal children.
News & Events
Major funding aims to improve skin cancer outcomes for young Aboriginal peopleVital research promoting sun smart choices and skin cancer prevention for young Aboriginal people is now underway at The Kids Research Institute Australia thanks to a $100,000 Perpetual 2024 IMPACT Philanthropy grant.
News & Events
Sophisticated modelling shows WA’s Omicron outbreak still has months to runWestern Australia’s Omicron outbreak is far from over, with new modelling showing the number of total infections is only at its half-way point.
News & Events
Projects to probe role of dads and help parents navigate teens’ digital worldA project that will investigate the role of Australian fathers in their children’s wellbeing and another which aims to help parents grapple with the digital world and its role in teens’ mental health have received significant funding from the Australian Research Council.
Research
Data for policyThe ultimate goal of this project is to enable policy-makers and researchers to work together to influence positive changes in the life trajectories of disadvantaged Australians via research driven policy initiatives.
News & Events
Why it’s safe for kids to be at schoolAs Australia battles with COVID-19 outbreaks across all mainland states, there is a sense of familiar dread as major cities plunge into lockdown.