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Beta-lactam-induced immediate hypersensitivity reactions: A genome-wide association study of a deeply phenotyped cohortBackground: β-lactam antibiotics are associated with a variety of immune-mediated or hypersensitivity reactions, including immediate (type I) reactions mediated by antigen-specific IgE. Objective: We sought to identify genetic predisposing factors for immediate reactions to β-lactam antibiotics.
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Status and Potential of Single-Cell Transcriptomics for Understanding Plant Development and Functional BiologyThe advent of modern "omics" technologies (genomics, transcriptomics, proteomics, and metabolomics) are attributed to innovative breakthroughs in genome sequencing, bioinformatics, and analytic tools. An organism's biological structure and function is the result of the concerted action of single cells in different tissues.
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Parainfluenza Virus Infection in an Australian Community-based Birth CohortIn a community-based birth cohort of 158 Australian infants followed to age 2 years, the incidence rate of human parainfluenza virus (HPIV) was 0.42 (95% CI = 0.33, 0.54) episodes per child-year with episodes occurring year-round, peaking in the spring season.
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Aquatic high intensity interval training to improve aerobic capacity is feasible in adolescents with cerebral palsy: pilot randomised controlled trialTo investigate feasibility of aquatic high intensity interval training for adolescents with cerebral palsy, who can ambulate independently but may choose a mobility aid in some circumstances.
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Panel 8: Vaccines and immunologyReview and highlight of the significant advances made towards vaccine development and understanding of the immunology of otitis media
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Antibiotics versus topical antiseptics for chronic suppurative otitis mediaTreatment of chronic suppurative otitis media with topical antibiotics probably results in an increase in resolution of ear discharge compared with boric acid
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Spaceship earth revisited: The co‐benefits of overcoming biological extinction of experience at the level of person, place and planetThis commentary focuses the ways in which microbes, as an essential part of all ecosystems, provide a vital link between personal and planetary systems
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Hearing aid review appointment: clients’ reasons for attendance and non-attendanceAppointment attendance is influenced by some factors modifiable by the clinician, including providing better education
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The effect of upgrades to childcare outdoor spaces on preschoolers’ physical activity: Findings from a natural experimentThis natural experiment investigated the influence of early childhood education and care outdoor physical environment upgrade on preschoolers' physical activity
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Differences in stroke risk and cardiovascular mortality for Aboriginal and other Australian patients with atrial fibrillationStroke risk and cardiovascular mortality are markedly higher for Aboriginal than non-Aboriginal patients with atrial fibrillation, particularly for patients under 60