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Immune checkpoint blockade (ICB) evokes antitumor immunity through the reinvigoration of T cell responses. T cell differentiation status controls response, with less differentiated cells having an enhanced capacity to proliferate after ICB. Given that conventional type 1 dendritic cells (cDC1) maintain precursor exhausted T cells (TPEX), we hypothesized that expansion of cDC1s with Flt3L could enhance responses to ICB.
Dental caries remains the most common chronic childhood condition and in Australia persists as a leading cause of potentially preventable hospitalisation. Despite various public health initiatives and improvements in oral health among the wider community, significant disparities exist among refugee families due to the unique challenges they face.
The Education Department of Western Australia advocates for culturally responsive schools. Aboriginal Indigenous Education Officers are employed by schools to facilitate and enable the potential for Aboriginal school children to thrive in school settings.
Citation: Arishi AA, Holland DC, Bracegirdle J, …… Garratt LW, Mantjani L, Moggach SA, et al. Genome-Guided Discovery and Heterologous Biosynthesis
Every child deserves the best possible start in life. Evidence demonstrates the period from pre-birth to three years is a vital period of development. It lays the foundations for a child’s future and has life-long impacts on health, education, job opportunities, social inclusion and wellbeing.
A Network comprised of four regional sites to facilitate key medical, research and training activities undertaken in partnership with Aboriginal communities.
The WAACHS regional profiles look at all four volumes of results across the ATSIC regions of Western Australia.
At The Kids Research Institute Australia, we've been thinking of the kids for 35 years. We are finding the answers to some of the biggest problems facing the health and wellbeing of children and families. Our Research Themes host defined programs of work where the Institute has clear strengths and capacity. Our overarching commitment to First Nations Health and Equity is embedded across all our work and features as a core consideration in each Research Theme. The Institute is committed to ending the disparity in health and wellbeing outcomes between Aboriginal and non-Aboriginal kids and families.
CREAHW is a program of intervention research focused on achieving sustainable change for the Aboriginal community & improving the lives of Aboriginal people.
The social and emotional wellbeing of Aboriginal children and young people