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Research

"Pre-emptive strike"-the case for early treatment of hepatic sinusoidal obstruction syndrome with defibrotide

We describe the case of a child with a right 11th rib primitive neuroectodermal tumor who developed HSOS following focal radiotherapy and actinomycin-D treatment

Research

The importance of the exposome and allostatic load in the planetary health paradigm

The concept of planetary health emphasizes that human health is intricately connected to the health of natural systems within the Earth's biosphere

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Discovery of Transcription Factors Novel to Mouse Cerebellar Granule Cell Development Through Laser-Capture Microdissection

This study provides an initial insight into the TFs of cerebellar granule cells that might be important for development

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Cord Blood IL-12 Confers Protection to Clinical Malaria in Early Childhood Life

Cord blood background IL-12 concentrations are important for protecting children from clinical malaria

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Parent-observed thematic data on quality of life in children with autism spectrum disorder

Parent observations provide an initial framework for understanding quality of life in autism spectrum disorder

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The Impact of Pneumococcal Vaccination on Bacterial and Viral Pneumonia in Western Australian Children: Record Linkage Cohort Study of 469589 Births, 1996-2012

We assessed the impact of PCV on all-cause and pathogen-specific pneumonia hospitalizations in Western Australian (WA) children aged 16 years.

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Choice making in Rett syndrome: a descriptive study using video data

We describe the choice-making abilities of girls and women with Rett syndrome.

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Educational inequality across three generations in Australia

Using a dataset of Australian children, we have the opportunity to not only investigate the transfer of educational resources across 3 generations in Australia.

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The Diverse Risk Profiles of Persistently Absent Primary Students: Implications for Attendance Policies in Australia

Understanding variations in risk profiles among persistently non-attending children will inform the development of absence interventions.

Research

The potential of antisense oligonucleotide therapies for inherited childhood lung diseases

Antisense oligonucleotides are an emerging therapeutic option to treat diseases with known genetic origin. In the age of personalised medicines, antisense oligonucleotides can sometimes be designed to target and bypass or overcome a patient's genetic mutation, in particular those lesions that compromise normal pre-mRNA processing. Antisense oligonucleotides can alter gene expression through a variety of mechanisms as determined by the chemistry and antisense oligomer design.