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An unopposed proinflammatory response is beneficial for survival in the oldest old. Results of the Leiden 85-plus studyThe capacity to generate an efficient innate immune response is pivotal for survival.
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Genetic and functional evidence implicating DLL1 as the gene that influences susceptibilityVisceral leishmaniasis (VL) is caused by Leishmania donovani and Leishmania infantum chagasi. Genome-wide linkage studies from Sudan and Brazil identified...
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Sexual dimorphism in lung function responses to acute influenza A infectionMales are generally more susceptible to respiratory infections; however, there are few data on the physiological responses to such infections in males and...
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Regulatory role of IL10 genetic variations in determining allergen-induced TH2 cytokine responses in childrenInterleukin-10 is a key immunomodulatory cytokine the principal function of which is to limit the magnitude of immune response.
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Gender-specific differences in adipose distribution and adipocytokines influence adolescent nonalcoholic fatty liver diseaseNonalcoholic fatty liver disease (NAFLD) is a predominantly adult-diagnosed disorder. Knowledge regarding the epidemiology, phenotype, and metabolic risk...
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Neck/shoulder pain, habitual spinal posture and computer use in adolescents: The importance of genderThe study aimed to examine the influence of gender on relationships between computer use, habitual posture and neck/shoulder pain.
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Identification and genetic determination of an early life risk disposition for depressive disorder:Progress in psychiatric genetics has been slow despite evidence of high heritability for most mental disorders
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Linking a pharmaceutical claims database with a birth defects registry to investigate birth defect rates of suspected teratogensData linkage of population administrative data is being investigated as a tool for pharmacovigilance in pregnancy in Australia.
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Antecedents of hospital admission for deliberate self-harm from a 14-year follow-up study using data-linkageA prior episode of deliberate self-harm (DSH) is one of the strongest predictors of future completed suicide. Identifying antecedents of DSH may inform strategi
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Association of an allele on chromosome 9 and abdominal aortic aneurysmAbdominal aortic aneurysm (AAA) has been recognized as a multi-factorial disease with both genetic and environmental risk factors.