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Research
PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding proteinOur findings present a novel mouse model for glioma demonstrating that the PI3K pathway is important for initiation of tumorigenesis
Research
Cochrane corner: hearing aids for mild to moderate hearing loss in adultsThe evidence supports the widespread provision of hearing aids as the first-line clinical management for those seeking help for hearing difficulties
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Exposure to chorioamnionitis alters the monocyte transcriptional response to the neonatal pathogen Staphylococcus epidermidisOur findings suggest that prenatal exposure to inflammation may alter the risk of sepsis in preterm infants partly by modulation of monocyte responses to pathogens
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Tryptophan and arginine catabolic enzymes and regulatory cytokines in clinically isolated syndrome and multiple sclerosisHigher IDO and ARG expression in clinically isolated syndrome and multiple sclerosis provides one sustained homeostatic mechanism to control multiple sclerosis-associated inflammation
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Structure-function relationships of the neisserial EptA enzyme responsible for phosphoethanolamine decoration of lipid A: Rationale for drug targetingThis review concentrates on the phosphoethanolamine decoration of lipid A in the pathogenic species of the genus Neisseria
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Airway function in infancy is linked to airflow measurements and respiratory symptoms from childhood into adulthoodLung airflow measurements track from birth into early adulthood, suggesting a permanent and stable airway framework is laid down in the antenatal period
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Environmental and social determinants of acute rheumatic fever: a longitudinal cohort studyPrevention strategies in ARF endemic settings may be enhanced by targeting new members entering a community and children in environments of close contact
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The ORIGINS ProjectORIGINS is a new birth cohort study, collecting detailed information about the early environment's influence on a broad range of non-communicable diseases
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Risk of Developmental Disorders in Children of Immigrant Mothers: A Population-Based Data Linkage EvaluationIncreased risk of autism spectrum disorder with intellectual disability and cerebral palsy with intellectual disability for mothers of some foreign-born groups
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Maternal pre-pregnancy weight and autistic-like traits among offspring in the general populationThis study provides further evidence that maternal pre-pregnancy obesity is associated with autism-like behaviors in offspring