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Research
Timing and temporal trends of influenza and pertussis vaccinations during pregnancy in three Australian jurisdictions: The Links2HealthierBubs population-based linked cohort study, 2012–2017Antenatal inactivated influenza and pertussis-containing vaccines offer protection against severe respiratory infections for pregnant women and infants <6 months of age. Both vaccines are recommended in pregnancy; however, little is known about temporal or jurisdictional trends and predictors of uptake.
Research
A phase 3, multicenter, randomized, double-blind study to evaluate the interchangeability of V114, a 15-valent pneumococcal conjugate vaccine, and PCV13 with respect to safety, tolerability, and immunogenicity in healthy infants (PNEU-DIRECTION)Pneumococcal disease (PD) remains a major health concern globally. In children, pneumococcal conjugate vaccines (PCVs) provide protection against PD from most vaccine serotypes, but non-vaccine serotypes contribute to residual disease. V114 is a 15-valent PCV containing all 13 serotypes in Prevnar 13™ and public health important serotypes 22F and 33F. This phase 3 study evaluated safety and immunogenicity of mixed PCV13/V114 regimens using a 3 + 1 dosing schedule when changing from PCV13 to V114 at doses 2, 3, or 4.
Research
Use of Neuroimaging to Predict Adverse Developmental Outcomes in High-Risk InfantsWith advances in perinatal care, we have achieved major reductions in mortality in premature and critically ill infants, but they still remain at increased risk of neurodevelopmental disability. In this context, recent advances in neuroimaging are perceived as an addition of significant value to current clinical developmental screening programs.
Research
Parents' COVID-19 vaccine intentions for children under 5 years: Brief reflections from a qualitative studyAustralian authorities made COVID-19 vaccines available for children aged under 5 years old with serious comorbidities in August 2022. There is presently no universal programme for young children, but crucial to any rollout's success is whether parents are motivated and able to vaccinate. By examining parents' vaccine intentions, this study aims to inform current and future COVID-19 vaccine roll-outs for children aged under 5 years.
Research
Sexualized Images on Social Media and Adolescent Girls’ Mental Health: Qualitative Insights from Parents, School Support Service Staff and Youth Mental Health Service ProvidersThis research explored adults' perceptions of how sexualized images typically found on social media might influence adolescent girls' mental health, what support girls might need should they experience mental health difficulties, and how such difficulties could be prevented or reduced.
Research
Autophagy modulates growth and development in the moss Physcomitrium patensPhyscomitrium patens apical growing protonemal cells have the singularity that they continue to undergo cell divisions as the plant develops. This feature provides a valuable tool to study autophagy in the context of a multicellular apical growing tissue coupled to development. Herein, we showed that the core autophagy machinery is present in the moss P. patens, and characterized the 2D and 3D growth and development of atg5 and atg7 loss-of-function mutants under optimal and nutrient-deprived conditions.
News & Events
Getting kids off screens and back outsideOn average Australian children spend about 22 hours a week on a screen and six hours a week playing outside.
News & Events
Telethon smashes records as West Australians dig deep for sick kidsOver the weekend, ORIGINS staff were out in force in the phone rooms and in our ORIGINS Project booth at the Beneficiaries Expo at the Perth Convention and Exhibition Centre.
News & Events
Healthy lunchbox tipsA healthy lunchbox is important, as it provides the fuel for your child to get through their day of learning and play.
News & Events
Multimillion-dollar ORIGINS Project recruits 1000th family for global health studyProfessor Desiree Silva with the 1000th family - Jess, Michael and Eli The multimillion-dollar ORIGINS Project, an extensive community-based
News & Events
Good gut healthThe key to being well may be in your micriome. But do you even know what it is?
Determining the associations of sun exposure in early life on the development of non-communicable diseases.
RHINO researchers from The Kids' Wal-yan Respiratory Research Centre, will analyse ORIGINS data and turn it into meaningful respiratory and allergy outcome data that can be used by researchers around the world.
This sub-project aims to fill the gap in knowledge of the effects of climate change on child health and wellbeing in Australia, and to propose data-driven adaptation trials to counter the most serious impacts.
Understanding how families engage with screen technologies and how it may influence child development