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Strongyloidiasis, caused by the soil-transmitted helminth Strongyloides stercoralis, remains a neglected public health issue in Australia, particularly among remote Aboriginal and Torres Strait Islander communities. This study aimed to map the spatial distribution of strongyloidiasis and investigate associated socioecological factors to identify high-risk areas and guide targeted interventions in Australia.
First Nations women often experience harmful, inequitable maternity care, shaped by intergenerational trauma and culturally unsafe care. Historical forced removal of First Nations children has created enduring trauma that influences pregnancy and birthing experiences. In the Australian Capital Territory, maternity care is provided through Western biomedical systems, where increasing child protection interventions and fear of surveillance affect women's engagement with care.
To investigate the follow-up and outcomes of HIV-exposed infants in a setting of low HIV prevalence. This was a multicenter, retrospective study of live-born infants of women known to be living with HIV, at 9 tertiary pediatric centers in Australia and New Zealand from 2009-2025. Antenatal, perinatal, and postnatal data, and outcomes at clinic visits to 18 months of age were collected, including co-morbidities, development, and HIV results.
To evaluate the psychometric properties of the Quality of Life Inventory -Disability (QI-Disability) for individuals with Dravet syndrome (DS) or Lennox-Gastaut syndrome (LGS), two rare developmental and epileptic encephalopathy conditions.
Islet autoantibodies herald early type 1 diabetes. However, less is known of the evolution of autoantibodies to the islet autoantigen ZnT8. Our primary aim was to characterise the development of islet autoantibodies in a pregnancy-birth at-risk cohort and to provide new knowledge about ZnT8A.
Acute rheumatic fever is an immune-mediated condition triggered by Streptococcus pyogenes sore throat and possibly skin infection, with a substantial burden in resource-limited settings. Clinical decision rules (CDRs) are commonly used to guide antibiotic treatment of sore throat based on signs and symptoms, but their diagnostic accuracy varies by study and setting. This work aimed to assess the accuracy of multiple CDRs in Fiji to diagnose S. pyogenes sore throat.
Monoclonal antibodies are revolutionizing the landscape of current cancer treatment, bringing hope to patients with incurable cancers. B7-H3 (CD276) is an attractive therapeutic target for antibody-based therapy due to its low or absent expression in normal tissues and high expression in various types of tumors, including prostate cancer, pancreatic cancer, and high-mortality esophageal squamous cell carcinoma (ESCC). In recent years, various B7-H3-targeting antibodies have been developed for cancer treatment, with a few making their way to clinical trials.
CliniKids, the first stand-alone clinical service offered by The Kids Research Institute Australia, was launched in October 2019 and is already delivering benefits for families with children who are developing differently.
A comprehensive app produced by The Kids researchers has offered parents a lifeline as they try to cope with the isolation and disruption caused by coronavirus.
An international clinical trial led by The Kids Research Institute Australia Cancer Centre is trialling a drug which could increase cure rates for aggressive forms of childhood brain cancer.