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T cells recognizing a 11mer influenza peptide complexed to H-2D b show promiscuity for peptide lengthT-cell repertoire is selected according to self peptide-MHC (major histocompatibility complex) complexes in the thymus.
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ARHGEF12 influences the risk of glaucoma by increasing intraocular pressure.Two important risk factors for this disease are a positive family history and elevated intraocular pressure (IOP), which is also highly heritable.
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Cancer and mental illness: Key issues in mental healthOver many years, it has been shown that cancer represents a significant proportion of excess mortality for people with mental illness.
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The valuing of upstream approaches across the lifecourse. Fact Sheet 2 for the Aboriginal and Torres Strait Islander Suicide Prevention Evaluation ProjectThis factsheet highlights the need for a greater understanding of the importance of constructive & preventive ‘upstream’ approaches & sustained investment in...
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Evaluation in health promotion: Thoughts from inside a human research ethics committeeHealth promotion research, quality improvement and evaluation are all activities that raise ethical issues.
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Utility of auscultatory screening for detecting rheumatic heart disease in high-risk children in Australia's Northern TerritorySensitivity and positive predictive value of cardiac auscultation compared with echocardiography is poor, regardless of the expertise of the auscultator.
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Analysis of baseline hypothalamic-pituitary-adrenal activity in late adolescence reveals gender specific sensitivity of the stress axisWe aimed to investigate basal HPA-activity in a normal population in late adolescence, the time of life believed to overlap with HPA-axis maturation...
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Diverging Trends in Gastroenteritis Hospitalizations during Two Decades in Western Australian Aboriginal and Non-Aboriginal ChildrenOur findings highlight the need to consider age, ethnicity, seasonality and climate when evaluating rotavirus vaccine programs.
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An Official ATS/ERS Workshop Report: Evaluation of Respiratory Mechanics and Function in the Pediatric and Neonatal Intensive Care UnitsThis report summarizes techniques available for ventilated and spontaneously breathing infants and children in the ICU
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Functional annotation of the vlinc class of non-coding RNAs using systems biology approachWe show that vlincRNAs genes likely function in cis to activate nearby genes