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Research that maps and tracks.

Research

A range of microbiota species correlate with improved cancer outcomes in patients and confer protection in pre-clinical mouse models. Here, we examined how microbiota regulate CD8+ T cell immunity against melanoma. Spontaneous control of cutaneous melanoma in mice correlated with metabolic pathways required for microbial synthesis of short-chain fatty acids (SCFAs) shared between several microbiota species.

Research

Human milk oligosaccharides (HMOs) are bioactive carbohydrates abundant in human milk that shape the infant gut microbiome, yet their influence on the oral microbiome remains poorly understood. This study investigated associations between HMO concentrations and infant HMO intakes and the composition of the oral microbiome in predominantly and exclusively breastfed infants.

In close partnership with Aboriginal Elders and community members in Western Australia's south-west, we created ‘Kaal Tackles Eczema’, a children’s book to help Aboriginal families manage eczema. Our research showed a high prevalence and need for culturally relevant resources. The book uses Noongar language and art to educate and reduce infections, and is available online and in schools.

Two international trials led by The Kids Research Institute Australia’s Neonatal and Infection Immunity Team are tackling the urgent need for simple and safe interventions that can help prevent the adverse long-term effects of infections in extremely preterm babies.

CliniKids, the first stand-alone clinical service offered by The Kids Research Institute Australia, was launched in October 2019 and is already delivering benefits for families with children who are developing differently.

An international clinical trial led by The Kids Research Institute Australia Cancer Centre is trialling a drug which could increase cure rates for aggressive forms of childhood brain cancer.

The ORIGINS Project, a collaboration between The Kids and Joondalup Health Campus, is collecting data and biological samples from 10,000 families over 10 years. Its work is also giving participating families a valuable heads up on health issues.

A program unfolding in four very diverse locations across Western Australia is working to give children aged 0–4 the best start in life.

Strong advocacy efforts have paid off with health and food safety ministers from around Australia and New Zealand finally approving the recommended version of a warning label designed to highlight the potential risks of alcohol during pregnancy.