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P4 Respiratory Health for Kids

The P4 Respiratory Health for Kids Team is a multi-disciplinary group with skills in clinical medicine, physiology, psychology, and in cellular and molecular biology, that are committed to improving the lives of children with respiratory diseases and their families.

Through local, national and international collaborations, the team will accelerate innovation in child respiratory health and translation of these discoveries into clinical practice and policy.

A major area of focus for the team is Cystic Fibrosis (CF), the most common chronic, life-shortening genetic condition affecting Australians. Our team leads the Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST CF), a collaborative group of over 30 doctors, allied health professionals and researchers dedicated to improving the respiratory health of children with CF by translating scientific research into tangible clinical outcomes. Research by our group and others has shown that infants and children with CF exhibit reduced lung function and evidence of inflammation and infection at a very early age. This highlights the need for new treatments that can be given from time of diagnosis to prevent and/or reverse the damage.

Learn more about the AREST team here.

Team leader

Stephen Stick
Stephen Stick

MB BChir PhD MRCP FRACP

Head, P4 Respiratory Health for Kids

Team members (23)

Helga Mikkelsen
Helga Mikkelsen

BSc MSc PhD Cantab

Project Manager, Respiratory Health

AI and Data Analytics Lead, Respiratory Research

Postdoctoral Research Officer

Laura Akesson

Laura Akesson

Honorary Research Associate

Georgia Banton

Georgia Banton

Clinical Trial Coordinator

Josh Beeson

Josh Beeson

Project Officer

Oded Breuer

Oded Breuer

Honorary Research Fellow

Daan Caudri

Daan Caudri

Honorary Research Fellow

Barry Clements

Barry Clements

Honorary Research Fellow

Eleanor Ferguson

Eleanor Ferguson

Clinical Trials Coordinator

Alexia Foti

Alexia Foti

Project Manager, Synergy

Sam Eastcott

Sam Eastcott

Clinical Trial Manager

Alphons Gwatimba

Alphons Gwatimba

Research Associate in AI

Alya Ishak

Alya Ishak

Collaborator

Yuliya Karpievitch

Yuliya Karpievitch

AI and Data Analyst, Biostatistician

Rebecca Langford

Rebecca Langford

Program Manager, Cystic Fibrosis Research

Kak-Ming Ling

Kak-Ming Ling

Research Assistant

Jaqueline Macpherson

Jaqueline Macpherson

Research Coordinator

Fergal O'Gara

Fergal O'Gara

Honorary Distinguished Research Associate

Liz Starcevich

Liz Starcevich

Research Study Coordinator

José Caparrós Martín

José Caparrós Martín

Research Fellow

Clare Berry

Clare Berry

Program Manager, Wal-yan Respiratory Research Centre

David Hancock

David Hancock

Honorary Research Fellow Team Member

P4 Respiratory Health for Kids projects

Featured projects

SYNERGY CF: Getting the best start to life - preventing early cystic fibrosis lung disease by solving the host-inflammation infection conundrum

SHIP CT: A Phase 3 randomised, double-blind, controlled trial of inhaled 7% hypertonic saline versus 0.9% isotonic saline for 48 weeks in patients with Cystic Fibrosis at 3-6 years of age in parallel with the North American SHIP clinical trial.

SHIP-CT, led by Professor Stephen Stick, Director of the Wal-yan Respiratory Research Centre at The Kids, is a unique study in preschool-aged children (from 3-6 years of age) with CF using images of the lung from chest CT scans as the main outcome measure.

Reports and Findings

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Lentiviral vector gene therapy and CFTR modulators show comparable effectiveness in cystic fibrosis rat airway models

Mutation-agnostic treatments such as airway gene therapy have the potential to treat any individual with cystic fibrosis (CF), irrespective of their CF transmembrane conductance regulator (CFTR) gene variants. The aim of this study was to employ two CF rat models, Phe508del and CFTR knockout to assess the comparative effectiveness of CFTR modulators and lentiviral vector-mediated gene therapy. 

Transcriptomic analysis of primary nasal epithelial cells reveals altered interferon signalling in preterm birth survivors at one year of age

Many survivors of preterm birth (<37 weeks gestation) have lifelong respiratory deficits, the drivers of which remain unknown. Influencers of pathophysiological outcomes are often detectable at the gene level and pinpointing these differences can help guide targeted research and interventions. This study provides the first transcriptomic analysis of primary nasal airway epithelial cells in survivors of preterm birth at approximately 1 year of age.

Exploring the Complexity of the Human Respiratory Virome through an In Silico Analysis of Shotgun Metagenomic Data Retrieved from Public Repositories

Respiratory viruses significantly impact global morbidity and mortality, causing more disease in humans than any other infectious agent. Beyond pathogens, various viruses and bacteria colonize the respiratory tract without causing disease, potentially influencing respiratory diseases’ pathogenesis.

The longitudinal microbial and metabolic landscape of infant cystic fibrosis: the gut-lung axis

In cystic fibrosis, gastrointestinal dysfunction and lower airway infection occur early and are independently associated with poorer outcomes in childhood. This study aimed to define the relationship between the microbiota at each niche during the first 2 years of life, its association with growth and airway inflammation, and explanatory features in the metabolome. 

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