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Vitamin D supplementation of initially vitamin D-deficient mice diminishes lung inflammation with limited effects on pulmonary epithelial integrityIn disease settings, vitamin D may be important for maintaining optimal lung epithelial integrity and suppressing inflammation, but less is known of its effects prior to disease onset.
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Persistent and compartmentalised disruption of dendritic cell subpopulations in the lung following influenza A virus infectionImmunological homeostasis in the respiratory tract is thought to require balanced interactions between networks of dendritic cell (DC) subsets in lung...
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Sensitizing and Th2 Adjuvant Activity of Cysteine Protease AllergensHere, we report on a model that does not use Th2-skewing adjuvants and yet achieves sensitization solely via the nasal mucosa.
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In utero cigarette smoke exposure impairs somatic and lung growth in BALB/c miceThe aim of this study was to assess whether in utero tobacco smoke exposure alone affects early-life lung growth and development. Pregnant BALB/c mice...
The Respiratory Environmental Health team conducts research in early life determinants of lung growth and development, respiratory environmental health, and mechanisms of airway dysfunction in asthma and other respiratory disease.
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Fetal alcohol exposure, nutritional status and epigenetic disruption – exploring the linksAlexander David Martyn Larcombe Martino Symons BScEnv (Hons) PhD BSc PhD B.A. (Hons) PhD. Honorary Research Fellow Head, Chronic Diseases Research
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The health effects of electronic cigarettesAlexander Larcombe BScEnv (Hons) PhD Honorary Research Fellow Honorary Research Fellow Associate Professor Alexander Larcombe began work at The Kids
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Alcohol pharmacotherapy dispensing trends in Australia between 2006 and 2023This study aimed to investigate acamprosate and naltrexone dispensing patterns in Australia.
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Stiffness Mediated-Mechanosensation of Airway Smooth Muscle Cells on Linear Stiffness Gradient HydrogelsIn obstructive airway diseases such as asthma and chronic obstructive pulmonary disease (COPD), the extracellular matrix (ECM) protein amount and composition of the airway smooth muscle (ASM) is often remodelled, likely altering tissue stiffness. The underlying mechanism of how human ASM cell (hASMC) mechanosenses the aberrant microenvironment is not well understood.
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Intrauterine growth restriction affects diaphragm function in adult female and male miceSex and intrauterine growth restriction independently affect diaphragm contraction in adult mice without changes in structure