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These results highlight how UNICORN can enable reliable, powerful, and convenient genetic association analyses without access to the individual-level data
Findings from this study indicate that even in the absence of stroke, being at high polygenic risk of ischemic stroke is associated with lower cognitive ability
TNF mRNA expression was higher in leprosy patients compared to endemic controls, but did not differ significantly between clinical subgroups
We investigated the prevalence of UDT and examined rates of surgery and age at surgery in an Australian population.
The transforming growth factor-beta pathway is important in the immunopathogenesis of Visceral leishmaniasis
Establishing a genomic reference for Australian Aboriginal populations
The cloning of herpesviruses as bacterial artificial chromosomes (BAC) has revolutionized the study of herpesvirus biology, allowing rapid and precise manipulation of viral genomes. Several clinical strains of human cytomegalovirus (HCMV) have been cloned as BACs; however, no low-passage strains of murine CMV, which provide a model mimicking these isolates, have been cloned. Here, the low-passage G4 strain of was BAC cloned. G4 carries an m157 gene that does not ligate the natural killer cell-activating receptor, Ly49H, meaning that unlike laboratory strains of MCMV, this virus replicates well in C57BL/6 mice.
GWAS results provide firm confirmation for the importance of antigen presentation and the regulation of IFNγ in determining the outcome of Leishmania infections
Our data set provides a useful reference point for genomic studies on Aboriginal Australians
There is insufficient evidence available to determine whether these organisms are pathogens, commensals or contribute indirectly to the pathogenesis of OM