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Impact of Childhood Pneumococcal Conjugate Vaccine on Nonnotified Clinically Suspected Invasive Pneumococcal Disease in AustraliaThis study provides a quantitative estimate of the total burden of invasive pneumococcal disease preventable by vaccination programs in Australia
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A cluster-randomised controlled trial comparing school and community-based deworming for soil transmitted helminth control in school-age childrenThe first large-scale trial comparing mass and targeted deworming for soil-transmitted helminth control in South East Asia
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Meningococcal serotype W septic arthritis: Case series in childrenThe epidemiology of invasive meningococcal disease has changed over the last decade and there has been an increase in cases caused by serogroup W135, particularly in Indigenous children. Extra‐meningeal and atypical presentations are associated with serogroup W and may delay diagnosis and therefore appropriate treatment. Public and clinician awareness are essential in facilitating effective new vaccine schedule implementation.
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The pharmacokinetic properties of artemether and lumefantrine in Malaysian patients with Plasmodium knowlesi malariaThe aim of this study was to assess the pharmacokinetic properties of artemether, lumefantrine and their active metabolites in Plasmodium knowlesi malaria.
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A platform in the use of medicines to treat chronic hepatitis C (PLATINUM C): protocol for a prospective treatment registry of real-world outcomes for hepatitis CSafe, highly curative, short course, direct acting antiviral (DAA) therapies are now available to treat chronic hepatitis C. DAA therapy is freely available to all adults chronically infected with the hepatitis C virus (HCV) in Australia. If left untreated, hepatitis C may lead to progressive hepatic fibrosis, cirrhosis and hepatocellular carcinoma.
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Preparing for Life: Plasma Proteome Changes and Immune System Development During the First Week of Human LifeNeonates have heightened susceptibility to infections. The biological mechanisms are incompletely understood but thought to be related to age-specific adaptations in immunity due to resource constraints during immune system development and growth. We present here an extended analysis of our proteomics study of peripheral blood-plasma from a study of healthy full-term newborns delivered vaginally, collected at the day of birth and on day of life (DOL) 1, 3, or 7, to cover the first week of life. The plasma proteome was characterized by LC-MS using our established 96-well plate format plasma proteomics platform.
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Current Status of Schistosomiasis Control and Prospects for Elimination in the Dongting Lake Region of the People's Republic of ChinaSchistosomiasis japonica is an ancient parasitic disease that has severely impacted human health causing a substantial disease burden not only to the Chinese people but also residents of other countries such as the Philippines, Indonesia and, before the 1970s, Japan. Since the founding of the new People's Republic of China (P. R. China), effective control strategies have been implemented with the result that the prevalence of schistosomiasis japonica has decreased markedly in the past 70 years.
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Seasonal and regional patterns of lower leg cellulitis in Western AustraliaIn the warmer tropical regions of WA no seasonality was observed, but overall incidence of LLC presentations were higher
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The politics of picking: Selective vaccinators and population-level policyPublic health systems face tensions between individuals and the collective. Parents who selectively vaccinate demonstrate this tension
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Pcv7-and pcv10-vaccinated otitis-prone children in new zealand have similar pneumococcal and haemophilus influenzae densities in their nasopharynx and middle earPCV10 did not reduce NTHi density in the nasopharynx or middle ear, and was associated with increased pneumococcal nasopharyngeal density