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Genetic and epigenetic susceptibility to early life infectionTo date there have been relatively few studies on genetic determinants of susceptibility to neonatal infection and many of these have methodological...
Research
A phase 2 open-label safety and immunogenicity study of a meningococcal B bivalent rLP2086 vaccine in healthy adultsNo currently licensed and available vaccine has been shown to provide broad protection against endemic MnB disease.
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No dose-dependent increase in fracture risk after long-term exposure to high doses of retinol or beta-caroteneThis intervention study found no increase in fracture risk among 2,322 adults who took a controlled, high-dose retinol supplement (25,000 IU retinyl...
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Familial aggregation of malignant mesothelioma in former workers and residents of Wittenoom, Western AustraliaClustering of cases of malignant mesothelioma within families has often been observed, but disentangling genetic and exposure effects has not been done.
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Dietary fructose in relation to blood pressure and serum uric acid in adolescent boys and girlsEvidence that fructose intake may modify blood pressure is generally limited to adult populations.
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Use of data linkage to investigate the aetiology of acute lower respiratory infection hospitalisations in childrenThe aim was to document the aetiology of acute lower respiratory infection (ALRI) hospitalisations in Western Australian children
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Western Australian emergency department presentations related to child maltreatment and intentional injuryTo determine the proportion of child maltreatment-related emergency department presentations in WA and describe the types of injuries associated with them.
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Initial assessment of the StepWatch Activity Monitor™ to measure walking activity in Rett syndromeIn girls and women with Rett syndrome, we assessed the accuracy of the StepWatch Activity Monitor™ and investigated relationships between daily step counts,...
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Colostrum as a Protective Factor Against Peanut Allergy: Evidence From a Birth CohortFood allergy affects families' quality of life, can be lifelong and life-threatening, urging the identification of early modifiable risk factors. Formula feeding in the first days of life may increase the risk of cow's milk allergy, a risk often attributed to cow's milk allergens exposure. Early formula feeding also reduces the colostrum intake, the first 3 days' milk, which is rich in bioactive compounds critical for immune and gut health. This study investigates whether partial colostrum feeding increases the risk of food allergy beyond cow's milk.
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Content Validation of the Communication Inventory Disability–Observer Reported CID-ORCDKL5 deficiency disorder is a rare and severe developmental and epileptic encephalopathy that has profound effects on communication. It is essential that communication be measured accurately for upcoming gene therapy trials. The Communication Inventory Disability-Observer Reported was developed from a framework of communication derived from parent/caregiver interview data in consultation with disability and communication experts, and after reviewing concepts in existing measures.