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Although uncommon, invasive meningococcal disease (IMD) results in death in 5%-10% of cases in healthy children and adolescents. This study aimed to examine demographics, clinical presentation, treatment and outcomes of Australian children hospitalized with IMD during the introduction of the meningococcal vaccine program, overall and by serogroup/disease severity.
Influenza infection in young children has a significant impact on medication use, absenteeism and the use of health care service
Research priorities emphasise a focus on life participation, psychosocial well-being, impact on family and quality of care
The most urgent areas appear to be to continue monitoring the emergence of novel otopathogens, and the need to develop prevention and preventative therapies
We have demonstrated that a single dose of a closely related commensal can delay onset of NTHi otitis media in vivo
Our findings suggest that prenatal exposure to inflammation may alter the risk of sepsis in preterm infants partly by modulation of monocyte responses to pathogens
Vaccine-proximate febrile seizures accounted for a small proportion of all febrile seizures hospital presentations
Severe hospitalized varicella still occurs with a 1-dose varicella program, although predominantly in unvaccinated children
No significant associations were found between maternal inactivated influenza vaccine or pertussis vaccination in pregnancy and adverse birth outcomes
One dose of MenACWY-TT boosts protection against MenC in primed children, is safe and extends protection against MenA, MenW and MenY