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Research
Reduced heart rate variability in adults with autism spectrum disorderOur data suggest an overall dysregulation in resting autonomic activity in adults with autism spectrum disorder
Research
B Part of It School Leaver protocol: an observational study to assess the impact of a meningococcal serogroup B vaccine programme on carriage of Neisseria meningitidisThis study will assess the impact of MenB vaccine (4CMenB) on carriage prevalence in school leavers in South Australia
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Call for a national sore throat guidelineAustralia needs a single national pharyngitis guideline to assist in providing rational, consistent and timely antibiotic treatment to patients at high risk of ARF
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Gender-affirming hormones and surgery in transgender children and adolescentsThis Review explores the available published evidence on gender-affirming cross-sex hormone and surgical interventions in transgender children
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Still keen and committed: piloting an instrument for identifying positive veteran teachersInitial findings suggest the potential of the instrument in helping identifying positive veteran teachers within systems, as well as the voracity of the research approach
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The public health control of scabies: priorities for research and actionScabies causes considerable morbidity and leads to severe bacterial infection and immune-mediated disease
Research
Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastomaMedulloblastoma (MB) consists of four core molecular subgroups with distinct clinical features and prognoses. Treatment consists of surgery, followed by radiotherapy and cytotoxic chemotherapy. Despite this intensive approach, outcome remains dismal for patients with certain subtypes of MB, namely, MYC-amplified Group 3 and TP53-mutated SHH. Using high-throughput assays, six human MB cell lines were screened against a library of 3208 unique compounds. We identified 45 effective compounds from the screen and found that cell cycle checkpoint kinase (CHK1/2) inhibition synergistically enhanced the cytotoxic activity of clinically used chemotherapeutics cyclophosphamide, cisplatin, and gemcitabine.
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Discrete choice experiment to evaluate preferences of patients with cystic fibrosis among alternative treatment-related health outcomes: A protocolThe aim of this study is to identify and quantify the preferences of patients with cystic fibrosis regarding treatment outcomes
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Hospitalisations for maternal assault are associated with increased risk of child protection involvementChild maltreatment allegation is common in children following a maternal hospitalisation for assault
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Agreement between units of measure for paediatric antibiotic utilisation surveillance using hospital pharmacy supply dataAgreement between the DDD and vial-based measures of use supports the use of DDD for select antibiotics that may be targeted by antimicrobial stewardship programs