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Mapping the landscape of chromatin dynamics during naïve CD4+ T-cell activationT-cell activation induces context-specific gene expression programs that promote energy generation and biosynthesis, progression through the cell cycle and ultimately cell differentiation. The aim of this study was to apply the omni ATAC-seq method to characterize the landscape of chromatin changes induced by T-cell activation in mature naïve CD4+ T-cells.
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Insights into respiratory disease through bioinformaticsHere, we review the basic concepts in bioinformatics and genomic data analysis and illustrate the application of these tools to further our understanding of lung diseases
Researchers have made a world-first discovery on how to prevent severe respiratory infections in babies.
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Asthma: Acute asthma flare-up in school-age childrenThe aim of this study is to identify differences in immune cells that are involved in the disease.
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Breastfeeding and Neonatal Age Influence Neutrophil-Driven Ontogeny of Blood Cell Populations in the First Week of Human LifeThe first few days of life are characterized by rapid external and internal changes that require substantial immune system adaptations. Despite growing evidence of the impact of this period on lifelong immune health, this period remains largely uncharted.
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Immunoinflammatory responses to febrile lower respiratory infections in infants display uniquely complex/intense transcriptomic profilesthe association between infant LRTI and risk for persistent wheeze/asthma in this cohort is generally stronger for fLRTIs than for other infection categories
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Respiratory viral infections and host responses; insights from genomicsReview of the viral sensing pathways and organizing principles that govern the innate immune response to infection
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Rapid recruitment of CD14+ monocytes in experimentally induced allergic rhinitis in human subjectsMononuclear phagocyte population is directly involved in the production of proinflammatory chemokines that attract other immune cells
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A genomics-based approach to assessment of vaccine safety and immunogenicity in childrenThis methodology has significant potential to identify covert interactions between inflammatory pathways triggered by vaccination, and as such may be a...