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Interferon regulatory factor 7 regulates airway epithelial cell responses to human rhinovirus infectionIRF7 regulates the expression of genes involved in antiviral immunity, inflammation, and the response to oxidative stress during HRV infections in HBE cells
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Differential gene network analysis for the identification of asthma-associated therapeutic targets in allergen-specific T-helper memory responsesDifferential network analysis of allergen-induced CD4 T cell responses can unmask covert disease-associated genes and pin point novel therapeutic targets
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Intracellular growth of Mycobacterium avium subspecies and global transcriptional responses in human macrophages after infectionMycobacterium avium subsp. avium (Maa) and M. avium subsp. hominissuis (Mah) are environmental mycobacteria and significant opportunistic pathogens.
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Immunoinflammatory responses to febrile lower respiratory infections in infants display uniquely complex/intense transcriptomic profilesthe association between infant LRTI and risk for persistent wheeze/asthma in this cohort is generally stronger for fLRTIs than for other infection categories
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Rapid recruitment of CD14+ monocytes in experimentally induced allergic rhinitis in human subjectsMononuclear phagocyte population is directly involved in the production of proinflammatory chemokines that attract other immune cells
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Bilateral murine tumor models for characterizing the response to immune checkpoint blockadeThis protocol describes bilateral murine tumor models that display a symmetrical yet dichotomous response to immune checkpoint blockade
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Respiratory viral infections and host responses; insights from genomicsReview of the viral sensing pathways and organizing principles that govern the innate immune response to infection
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Breastfeeding and Neonatal Age Influence Neutrophil-Driven Ontogeny of Blood Cell Populations in the First Week of Human LifeThe first few days of life are characterized by rapid external and internal changes that require substantial immune system adaptations. Despite growing evidence of the impact of this period on lifelong immune health, this period remains largely uncharted.
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A genomics-based approach to assessment of vaccine safety and immunogenicity in childrenThis methodology has significant potential to identify covert interactions between inflammatory pathways triggered by vaccination, and as such may be a...