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AEC-conditioned DC showed selective upregulation of chemokines that recruit Th1 cells, but minimal change in chemokines linked to Th2 cell recruitment.

Here, we report on a model that does not use Th2-skewing adjuvants and yet achieves sensitization solely via the nasal mucosa.

Chronic innocuous aeroallergen exposure attenuates CD4+ T cell-mediated airways hyperresponsiveness in mice; however, the mechanism(s) remain unclear

It has been hypothesized that vitamin D deficiency (VDD) contributes to the development of food sensitization (FS) and then food allergy.

An improved understanding of the roles of protein kinases in intracellular signalling and disease progression has driven significant advances in protein...

Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease.

Airway epithelial cells act through multiple mechanisms to function as an important component of the pulmonary defence strategy that is crucial...

For 20 years, the hygiene hypothesis has dominated attempts to explain the increasing prevalence of allergic disease. A causal link between maternal innate immu

The house dust mite allergen Der p 2 is one of the most important indoor allergens associated with allergic disease.

Inhaled allergens are known for their immediate and ongoing effects in the respiratory tract (RT).