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25-hydroxyvitamin D3 status is associated with developing adaptive and innate immune responses in the first 6 months of lifeVitamin D status in early life has been linked to the risk of allergic disease in multiple observational studies.
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Effects of maternal dietary egg intake during early lactation on human milk ovalbumin concentration: A randomized controlled trialIncreased maternal egg ingestion is associated with increased breastmilk ovalbumin, and markers of immune tolerance in infants
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Maternal serum unmetabolized folic acid concentration following multivitamin and mineral supplementation with or without folic acid after 12 weeks gestation: A randomized controlled trialPregnant women are advised to take folic acid (FA) supplements before conception and during the first trimester of pregnancy. Many women continue FA supplementation throughout pregnancy, and concerns have been raised about associations between excessive FA intake and adverse maternal and child health outcomes.
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Ontogeny of toll-like and NOD-like receptor-mediated innate immune responses in Papua New Guinean infantsStudies addressing the ontogeny of the innate immune system in early life have reported mainly on Toll-like receptor (TLR) responses in infants living in...
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The SYMBA Study - Promoting Gut Health (SYMBiosis) for Allergy preventionDebbie Susan Desiree Palmer Prescott Silva BSc BND PhD MBBS BMedSci PhD FRACP MBBS, FRACP, MPH, PhD Head, Nutrition in Early Life Honorary Research
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Maternal Allergic Disease Phenotype and Infant Birth Season Influence the Human Milk MicrobiomeEarly infancy is a critical period for immune development. In addition to being the primary food source during early infancy, human milk also provides multiple bioactive components that shape the infant gut microbiome and immune system and provides a constant source of exposure to maternal microbiota. Given the potential interplay between allergic diseases and the human microbiome, this study aimed to characterise the milk microbiome of allergic mothers.
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Maternal prebiotic supplementation during pregnancy and lactation modifies the microbiome and short chain fatty acid profile of both mother and infantImproving maternal gut health in pregnancy and lactation is a potential strategy to improve immune and metabolic health in offspring and curtail the rising rates of inflammatory diseases linked to alterations in gut microbiota. Here, we investigate the effects of a maternal prebiotic supplement (galacto-oligosaccharides and fructo-oligosaccharides), ingested daily from <21 weeks' gestation to six months' post-partum, in a double-blinded, randomised placebo-controlled trial.
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Histological predictors of outcome for cutaneous squamous cell carcinoma in renal transplant patients: A case-control studyCutaneous squamous cell carcinoma is a significant cause of morbidity for immunosuppressed patients such as organ transplant recipients; however, histological parameters which predict the likelihood of tumor progression are typically based on general population studies in which immunosuppressed patients represent only a small fraction of cases.
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Food Proteins in Human Breast Milk and Probability of IgE-Mediated Allergic Reaction in Children During Breastfeeding: A Systematic ReviewPrevious reports suggested that food proteins present in human milk (HM) may trigger symptoms in allergic children during breastfeeding, but existing evidence has never been reviewed systematically.
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Higher maternal bread and thiamine intakes are associated with increased infant allergic diseaseA mother's diet during pregnancy may influence her infant's immune development. However, as potential interactions between components of our dietary intakes can make any nutritional analysis complex, here we took a multi-component dietary analysis approach.