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IRF7-Associated Immunophenotypes Have Dichotomous Responses to Virus/Allergen Coexposure and OM-85-Induced ReprogrammingHigh risk for virus-induced asthma exacerbations in children is associated with an IRF7lo immunophenotype, but the underlying mechanisms are unclear. Here, we applied a Systems Biology approach to an animal model comprising rat strains manifesting high versus low susceptibility to experimental asthma, induced by virus/allergen coexposure, to elucidate the mechanism(s)-of-action of the high-risk asthma immunophenotype.
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Demographic and clinical predictors of vitamin D status in pregnant women tested for deficiency in Western AustraliaThis study aimed to describe the vitamin D status of pregnant women in Western Australia and identify predictors of deficiency in pregnancy. A cross-sectional study was conducted using linked data from statewide administrative data collections.
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The current state of play of rodent models to study the role of vitamin D in UV-induced immunomodulationUltraviolet radiation (UVR) from sunlight is immunomodulatory and the main source of vitamin D for humans.
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Vitamin D 3 deficiency enhances allergen-induced lymphocyte responses in a mouse model of allergic airway diseaseIn this study, using a mouse model, we determined whether vitamin D deficiency in utero and during early life modulated the severity of asthma.
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Maternal Serum Vitamin D Levels During Pregnancy and Offspring Neurocognitive DevelopmentNew research links poor language to lack of Vitamin D in womb.
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UV exposure and protection against allergic airways diseaseAsthma is a chronic inflammatory disease of the small and large conducting airway mucosa characterised by Th2 cell immunity.
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Maternal Vitamin D Levels and the Autism Phenotype Among OffspringWe tested whether maternal vitamin D insufficiency during pregnancy is related to the autism phenotype.
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Toward homeostasis: Regulatory dendritic cells from the bone marrow of mice with inflammationInflammatory mediators from peripheral tissues may control dendritic cell (DC) development in the bone marrow.
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The anti-inflammatory actions of IL-4 in human monocytes are not mediated by IL-10, RP105 or the kinase activity of RIPK2The anti-inflammatory actions of IL-4 in activated human monocytes may reflect transcriptional regulation of genes involved in TLR signaling pathways.
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Vitamin D deficiency causes deficits in lung function and alters lung structureThe prevalence of vitamin D deficiency is increasing and has been linked to obstructive lung diseases including asthma and chronic obstructive pulmonary disease