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Research

Bioenergetic modulation overcomes glucocorticoid resistance in T-lineage acute lymphoblastic leukaemia

Drug-resistant forms of acute lymphoblastic leukaemia (ALL) are a leading cause of death from disease in children.

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Public-private collaboration in clinical research during pregnancy, lactation, and childhood

This position statement summarises a view of academia regarding standards for clinical research in collaboration with commercial enterprises, focussing on...

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Human rhinovirus species C infection in young children with acute wheeze is associated with increased acute respiratory hospital admissions

To determine whether acute wheezing exacerbations due to HRV-C are associated with increased hospital attendances due to acute respiratory illnesses (ARIs).

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Meeting the needs of young people in hospital

For hospital-based clinicians wishing to establish AYA services, how should they proceed and what might such services look like?

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Transition to secondary school: Expectation versus experience

This study investigated what young people in primary school reported being worried about with their impending move to secondary school, and how their...

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Is the effect of compulsory community treatment

We investigated whether a reduction of preventable deaths from physical disorders was mediated by better access to specialized medical procedures.

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Assessment and management of nutrition and growth in rett syndrome

We developed recommendations for the clinical management of poor growth and weight gain in Rett syndrome through evidence review and the consensus of an...

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Using a large international sample to investigate epilepsy in Rett syndrome

The aim of this study was to identify characteristics of epilepsy in Rett syndrome (RTT), and relationships between epilepsy and genotype.

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Altered immunity and dendritic cell activity in the periphery of mice after long-term engraftment with bone marrow from ultraviolet-irradiated mice

To investigate the immune capabilities of peripheral tissue DCs generated in vivo from the BM of UV-irradiated mice, chimeric mice were established.

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How Accurate Are International Classification of Diseases-10 Diagnosis Codes in Detecting Influenza and Pertussis Hospitalizations in Children?

Influenza diagnosis codes had high specificity (98.6%) and modest positive predictive value (PPV; 84.1%) and sensitivity (86.1%) for a laboratory-confirmed...