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Hypomethylation of the CTGF gene locus is a common feature of paediatric pre-B acute lymphoblastic leukaemiaWe identified consistent hypomethylation of the CTGF locus in primary pre-B ALL specimens regardless of CTGF expression.
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Are autistic traits in the general population stable across development?The current investigation measured AT in 360 males and 400 males from the general population close to two decades apart, using the Pervasive Developmental...
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Evaluating a community-based early childhood education and development program in Indonesia: study protocol for a pragmatic cluster randomized controlled trialThe aim of the trial is to evaluate a community-based early education and development program launched by the Government of Indonesia.
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Modulation of the immune system by UV radiation: More than just the effects of vitamin D?Humans obtain most of their vitamin D through the exposure of skin to sunlight
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Long-term outcome of insulin pump therapy in children with type 1 diabetes assessed in a large population-based case-control studyWe determined the impact of insulin pump therapy on long-term glycaemic control, BMI, rate of severe hypoglycaemia and diabetic ketoacidosis (DKA) in children.
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Restricted aeroallergen access to airway mucosal dendritic cells in vivo limits allergen-specificChronic innocuous aeroallergen exposure attenuates CD4+ T cell-mediated airways hyperresponsiveness in mice; however, the mechanism(s) remain unclear
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Mixed Proteasomes Function To Increase Viral Peptide Diversity and Broaden Antiviral CD8+ T Cell ResponsesMany proteasomes expressed by normal cells and cells exposed to cytokines are "mixed", that is, contain both standard and immunoproteasome subunits.
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The relationship between MECP2 mutation type and health status and service use trajectories over time in a Rett syndrome populationThis study aimed to investigate the trajectories over time of health status and health service use in Rett syndrome by mutation...
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The effect of midday moderate-intensity exercise on postexercise hypoglycemia risk in individuals with type 1 diabetesRecently we reported a biphasic increase in glucose requirements to maintain euglycemia after late-afternoon exercise, suggesting a unique pattern of delayed...
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Changes in health professionals' knowledge, attitudes and practice following provision of educational resourcesWe provided health professionals in Western Australia (WA) with educational resources about prevention of prenatal alcohol exposure and fetal alcohol...
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Breastfeeding and early child development: A prospective cohort studyBreastfeeding has been associated with multiple developmental advantages for the infant; however, there have also been a number of studies that find...
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Late-talking and risk for behavioural and emotional problems during childhood and adolescenceAlthough many toddlers with expressive vocabulary delay ("late talkers") present with age-appropriate language skills by the time they are of school age...
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Bronchial brushings for investigating airway inflammation and remodellingAsthma is the commonest medical cause for hospital admission for children in Australia, affects more than 300 million people worldwide, and is incurable...
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Does Exposure to Asbestos Cause Ovarian Cancer? A Systematic Literature Review and Meta-analysisThe asbestos and ovarian cancer relationship is not well understood because of small numbers of women exposed to asbestos, small numbers of cases...
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Opportunities and challenges of the pulmonary route for vaccinationThe respiratory tract is an attractive target for the delivery of vaccine antigens.