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The airway epithelium of both children and adults with asthma is relatively undifferentiated characterized by a significantly increased proportion of...
Our experiments provide proof of principle for the use of PSC-derived respiratory epithelial cells in the study of cell-virus interactions.
Chest computed tomography (CT) is the gold standard for demonstrating cystic fibrosis (CF) airway disease. However, there are no standardized outcome...
Airway inflammation and infection are present from early in life, often before children are symptomatic.
Biomarkers in cystic fibrosis are used for the measurement of cystic fibrosis transmembrane regulator function in order to diagnose cystic fibrosis,...
Determinants of culture success through retrospective analysis of a program of routinely brushing children with Cystic Fibrosis airway disease
A better understanding of the innate immune responses by CF airway epithelial cells is needed to identify why viral infections are more severe in CF
Comprehensive scores incorporating clinical, lung function, imaging and laboratory data will become essential in the future for predicting disease progression and for use in clinical trials
Interstitial lung disease in children comprises a range of different rare diseases
Here we review the current knowledge of key molecular pathways that are dysregulated during persistent goblet cell differentiation