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Identification of genes differentially regulated by vitamin D deficiency that alter lung pathophysiology and inflammation in allergic airways disease

Vitamin D deficiency exacerbates house dust mite-induced inflammation and alterations in lung structure and function

Rapid recruitment of CD14+ monocytes in experimentally induced allergic rhinitis in human subjects

Mononuclear phagocyte population is directly involved in the production of proinflammatory chemokines that attract other immune cells

Rhinovirus-induced asthma exacerbations and risk populations

Asthma exacerbations are heterogeneous conditions that involve the complex interplay between environmental exposures and innate and adaptive immune function

The effects of in utero vitamin D deficiency on airway smooth muscle mass and lung function

In this study, we aimed to uncover the molecular mechanisms contributing to altered lung structure and function.

Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinations

Cancer immunotherapy has shown impressive results, but most patients do not respond.

Genomic responses during acute human anaphylaxis are characterized by upregulation of innate inflammatory gene networks

The aim of this study was to examine the gene response of white blood cells in severe allergic reactions to identify genes that could be targets to new drugs...

In utero exposure to arsenic alters lung development and genes related to immune and mucociliary function in mice

In utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in...

Unlocking immune-mediated disease mechanisms with transcriptomics

The transcriptome represents the entire set of RNA transcripts expressed in a cell, reflecting both the underlying genetic and epigenetic landscape and environmental influences, providing a comprehensive view of functional cellular states at any given time. Recent technological advances now enable the study of the transcriptome at the resolution of individual cells, providing exciting opportunities to characterise cellular and molecular events that underpin immune-medicated diseases.

Transplacental Innate Immune Training via Maternal Microbial Exposure: Role of XBP1-ERN1 Axis in Dendritic Cell Precursor Programming

We recently reported that offspring of mice treated during pregnancy with the microbial-derived immunomodulator OM-85 manifest striking resistance to allergic airways inflammation, and localized the potential treatment target to fetal conventional dendritic cell (cDC) progenitors. Here, we profile maternal OM-85 treatment-associated transcriptomic signatures in fetal bone marrow, and identify a series of immunometabolic pathways which provide essential metabolites for accelerated myelopoiesis.

Airway Epithelial Cell Immunity Is Delayed During Rhinovirus Infection in Asthma and COPD

We propose that propensity for viral exacerbations of asthma and COPD relate to delayed expression of epithelial cell innate anti-viral immune genes