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An outpatient, ambulant-design, controlled human infection model using escalating doses of Salmonella Typhi challenge delivered in sodium bicarbonate solutionTyphoid fever is a major global health problem, the control of which is hindered by lack of a suitable animal model in which to study Salmonella Typhi...
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The challenge of enteric feverEnteric fever prevention requires significant long term investment in provision of clean water and sanitation; vaccination offers medium term control.
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Impact of CD14 promoter variants on measles vaccine responses and vaccine failure in children from Australia and MozambiqueHost genetics are likely to play a crucial role, particularly variants that alter key innate immune response genes.
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Safety surveillance of influenza vaccine in pregnant womenVaccination is the most effective strategy for preventing influenza infection in pregnancy.
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Immunogenicity and safety of measles-mumps-rubella and varicella vaccines coadministeredA pooled analysis was conducted of 1,257 toddlers who received a fourth dose of Haemophilus influenzae type b- Neisseria meningitidis serogroups C and...
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Respiratory viral pathogens associated with lower respiratory tract disease among young childrenAcute lower respiratory tract infections (ALRI) commonly result in fatal outcomes in the young children of Papua New Guinea (PNG).
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CD46 measles virus receptor polymorphisms influence receptor protein expressionDespite the availability of measles vaccines, infants continue to die from measles. Measles vaccine responses vary between individuals, and poor...
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Toll-like receptor 7 and 8 polymorphisms: Associations with functional effects and cellular and antibody responses to measles virus and vaccineThe functionality and effects of TLR7 and TLR8 polymorphisms on cellular and antibody responses was investigated after the first measles vaccine dose.
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Genetic and functional evidence implicating DLL1 as the gene that influences susceptibilityVisceral leishmaniasis (VL) is caused by Leishmania donovani and Leishmania infantum chagasi. Genome-wide linkage studies from Sudan and Brazil identified...
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Increased allergic immune response to Sarcoptes scabiei antigens in crusted versus ordinary scabiesScabies, a parasitic skin infestation by the burrowing "itch" mite Sarcoptes scabiei, causes significant health problems for children and adults worldwide.