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Research

Cerebral palsy and perinatal mortality after pregnancy-induced hypertension across the gestational age spectrum: Observations of a reconstructed total population cohort

This reconstructed total population cohort paper investigates the relationship between cerebral palsy & pregnancy induced hypertension.

Research

Autonomic nervous system dysfunction in psychiatric disorders and the impact of psychotropic medications: A systematic review and meta-analysis

Findings confirm substantial reductions in heart rate variability across psychiatric disorders, and remained significant even in medication-free individuals

Research

The role of preschool in promoting children’s healthy development: Evidence from an Australian population cohort

Engagement with preschool programs in Australia may present a plausible, equitable, and modifiable approach to improving children's developmental outcomes

Research

The relationship between central and peripheral oxytocin concentrations: A systematic review and meta-analysis protocol

Systematic review and meta-analysis will synthesize evidence to determine if there is an association between central and peripheral oxytocin concentrations

Research

A special supplement: Findings from the Australian Cerebral Palsy Register, birth years 1993 to 2006

A downward trend in rates of CP in those born extremely preterm was evident over at least three consecutive periods across all three regions.

Research

Lack of replication for the myosin-18B association with mathematical ability in independent cohorts

Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular...

Research

Risk of cancer among children with birth defects: A novel approach

This novel approach aimed to prevent inflated hazard ratios arising from reverse causation, and allow identification of associations beyond those already...

Research

Tonsils at Telethon: developing a standardised collection of tonsil photographs for group A streptococcal (GAS) research

Group A streptococcus (GAS) infections, such as pharyngitis and impetigo, can lead to rheumatic fever and rheumatic heart disease (RHD). Australian Aboriginal and Torres Strait Islander populations experience high rates of RHD and GAS skin infection, yet rates of GAS pharyngitis are unclear. 

Research

Recombinational exchange of M-fibril and T-pilus genes generates extensive cell surface diversity in the global group A Streptococcus population

Among genes present in all group A streptococci (GAS), those encoding M-fibril and T-pilus proteins display the highest levels of sequence diversity, giving rise to the two primary serological typing schemes historically used to define strain. A new genotyping scheme for the pilin adhesin and backbone genes is developed and, when combined with emm typing, provides an account of the global GAS strain population.

Research

Serological Responses to Streptococcus pyogenes Vaccine Candidate Antigens Suggests That Streptococcus dysgalactiae Is the Predominant Cause of Lower Limb Cellulitis

A future Streptococcus pyogenes (Strep A) vaccine will ideally prevent a significant burden of lower limb cellulitis; however, natural immune responses to proposed vaccine antigens following an episode of cellulitis remain uncharacterized.