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Rheumatic heart disease (RHD) after group A streptococcus (GAS) infections is heritable and prevalent in Indigenous populations. Molecular mimicry between human and GAS proteins triggers proinflammatory cardiac valve-reactive T cells.
Our results show perturbation of host mitochondrial function following T. gondii infection that likely impacts on pathogenesis of disease.
disease-deconvolution" identified associations between the parasite-brain interactions and epilepsy, movement disorders, Alzheimer's disease, and cancer.
Here we show that transfected macrophages stably expressing wild-type Nramp1 (Nramp1+) control the net replication of B. thailandensis, but not B. pseudomallei.
These results contribute to our understanding of immunopathology associated with visceral leishmaniasis and response to sodium stibogluconate treatment
We found no increased risk of poor development among boys with hypospadias or undescended testis
Here, we confirm four intercontinental species of avian trypanosomes in native Australian birds, and identify a new avian Trypanosoma.
Compared the in vitro susceptibility of two strains of Trypanosoma copemani and one strain of T. cruzi against drugs that show trypanocidal activity
We believe this data represents a useful resource to understand the central nervous system in macaque.
Combining these findings with conservation data, we identify 19,175 potentially functional lncRNAs in the human genome.