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Relationship between cytokine expression patterns and clinical outcomes: two population-based birth cohortsOur findings suggest that positive HDM 'allergy tests' and asthma are associated with a broad range of immunophenotypes, which may have important...
Research
Vitamin D status and predictors of serum 25-hydroxyvitamin D concentrations in Western Australian adolescentsUsing prospective data from the Western Australian Pregnancy Cohort (Raine) Study, we investigated vitamin D status and predictors of serum 25-hydroxyvitamin...
Research
Genetic polymorphism of KIR2DL4 (CD158d), a putative NK cell receptor for HLA-G, does not influence susceptibility to asthmaNo reproducible associations with KIR2DL4 genotype were identified, leading us to conclude that the KIR2DL4 9A/10A polymorphism has no influence...
Research
Neonatal antigen-presenting cells are functionally more quiescent in children born under traditional compared with modern environmental conditionsOne explanation for the high burden of allergic and autoimmune diseases in industrialized countries is inappropriate immune development under modern...
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Virus infection and allergy in the development of asthma: What is the connection?Information is accumulating which implicates airway inflammation resulting from respiratory viral infections, acting against a background of atopy.
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Maternal serum vitamin D levels during pregnancy and offspring neurocognitive developmentThe objective was to determine the association between maternal serum 25(OH)-vitamin D concentrations and behavioural, emotional and language outcomes...
Research
A novel role for interleukin-1 receptor signaling in the developmental regulation of immune responses to endotoxinSuggests that IL-1R1 expression provides an additional level of Myd88-dependent signaling during this period of heighted susceptibility to infection.
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T-cell activation genes differentially expressed at birth in CD4+ T-cells from children who develop IgE food allergyTo show underlying mechanisms, we examined differences in T-cell gene expression in samples at birth and at 1 year in children with and without IgE allergy.
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Risk factors for bronchial hyperresponsiveness in teenagers differ with sex and atopic statusSex-related differences in bronchial hyperresponsiveness (BHR) have been reported in adolescents, but the mechanisms remain obscure.
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Interaction between adaptive and innate immune pathways in the pathogenesis of atopic asthma: Operation of a lung/bone marrow axisAtopic asthma is the most common form of asthma, particularly during childhood, and in many cases it persists into adult life.