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Study protocol for a randomised controlled trial evaluating the effect of folic acid supplementation beyond the first trimester on maternal plasma unmetabolised folic acid in late gestationTaking folic acid containing supplements prior to and during early pregnancy reduces the risk of neural tube defects. Neural tube defects occur prior to 28 days postconception, after which, there is no proven benefit of continuing to take folic acid. However, many women continue to take folic acid containing supplements throughout the pregnancy.
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Deciphering the Immunological Phenomenon of Adaptive Natural Killer (NK) Cells and Cytomegalovirus (CMV)Natural killer (NK) cells play a significant and vital role in the first line of defense against infection through their ability to target cells without prior sensitization. They also contribute significantly to the activation and recruitment of both innate and adaptive immune cells through the production of a range of cytokines and chemokines. In the context of cytomegalovirus (CMV) infection, NK cells and CMV have co-evolved side by side to employ several mechanisms to evade one another.
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Bile Acid Signal Molecules Associate Temporally with Respiratory Inflammation and Microbiome Signatures in Clinically Stable Cystic Fibrosis PatientsCystic fibrosis (CF) is a congenital disorder resulting in a multisystemic impairment in ion homeostasis. The subsequent alteration of electrochemical gradients severely compromises the function of the airway epithelia.
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Spatial patterns of tuberculosis and HIV coinfection in EthiopiaOur study provides evidence for geographic clustering of tuberculosis/human immunodeficiency virus co-infection in Ethiopia
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Malt1 deficient mice develop osteoporosis independent of osteoclast-intrinsic effects of Malt1 deficiencyMalt1 deficient mice develop an osteoporotic phenotype with increased osteoclastogenesis in vivo, but suggest that this is caused by inflammation
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Bowel patterns, gastrointestinal symptoms, and emotional well-being in adolescents: A cohort studyIn adolescents, bowel patterns and gastrointestinal symptoms are diverse and show sex differences
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A role for affectivity in rapid facial mimicry: An electromyographic studyUsing a novel methodological approach, these findings provide evidence for the contention that affective processing underlies rapid facial mimicry reactions
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Maternal Smoking During Pregnancy Induces Epigenetic Changes Into Adolescence, Independent of Postnatal Smoke Exposure and Is Associated With Cardiometabolic RiskThis study demonstrates a critical timing of cigarette smoke exposure over the life course for establishing persistent changes in DNA methylation into adolescence
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Impaired T cell proliferation by ex vivo BET-inhibition impedes adoptive immunotherapy in a murine melanoma modelWe established a pipeline to assess the effects of epigenetic modifiers on CD8+ T cell proliferation, differentiation, and efficacy in a preclinical melanoma model
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Viral respiratory infections and the oropharyngeal bacterial microbiota in acutely wheezing childrenBacterial airway microbiome is highly variable in early life and its role in wheeze remains less clear than viral influences