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Research
The association between playgroup participation, learning competence and social-emotional wellbeing for children aged four-five years in AustraliaThis study provides evidence that continued participation in playgroups is associated with better outcomes for children from disadvantaged families.
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The Dyslexia Candidate Locus on 2p12 Is Associated with General Cognitive Ability and White Matter StructureTo further explore the effect of disorder-associated genes on cognitive functions, we investigated whether they play a role in broader cognitive traits.
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Neighbourhood Effects Influencing Early Childhood Development: Conceptual Model and Trial Measurement Methodologies from the Kids in Communities StudySocio-environmental factors, including the neighbourhoods in which children live and grow, are key determinants of children's developmental outcomes.
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Prevention - what is the most promising approach?This paper is an editorial comment by Professor Patrick Holt on the potential for developing early intervention strategies in children with allergies and asthma
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Interactions between acute lymphoblastic leukemia and bone marrow stromal cells influence response to therapyTo identify links between drug resistance and gene deregulation we used oligonucleotide microarray technology.
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Polyunsaturated fatty acid intake and blood pressure in adolescentsThis study examined cross-sectional associations between BP and dietary intake of PUFAs in 814 adolescents from the RAINE cohort study.
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Guidelines for pregnancy: What's an acceptable risk, and how is the evidence (finally) shaping up?This paper reviews the evidence from systematic reviews and meta-analyses examining the risk from low and moderate levels of prenatal alcohol exposure.
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Fetal alcohol spectrum disorder and the criminal justice systemFetal Alcohol Spectrum Disorder (FASD) is a condition caused by prenatal exposure to alcohol and characterised by severe neurodevelopmental impairment which have lifelong implications. Impairments in executive function, memory, cognition, language and attention are common, and can lead to early and repeat engagement with the criminal justice system.
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Tumour draining lymph node-generated CD8 T cells play a role in controlling lung metastases after a primary tumour is removed but not when adjuvant immunotherapy is usedSurgical resection of cancer remains the frontline therapy for millions of patients annually, but post-operative recurrence is common, with a relapse rate of around 45% for non-small cell lung cancer. The tumour draining lymph nodes (dLN) are resected at the time of surgery for staging purposes, and this cannot be a null event for patient survival and future response to immune checkpoint blockade treatment. This project investigates cancer surgery, lymphadenectomy, onset of metastatic disease, and response to immunotherapy in a novel model that closely reflects the clinical setting. In a murine metastatic lung cancer model, primary subcutaneous tumours were resected with associated dLNs remaining intact, completely resected or partially resected.
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Surfactant protein disorders in childhood interstitial lung diseaseSurfactant, which was first identified in the 1920s, is pivotal to lower the surface tension in alveoli of the lungs and helps to lower the work of breathing and prevents atelectasis. Surfactant proteins, such as surfactant protein B and surfactant protein C, contribute to function and stability of surfactant film.