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Respiratory Syncytial Virus Vaccination during Pregnancy and Effects in InfantsA multi-country randomized, placebo-controlled trial of the safety, immunogenicity and efficacy of respiratory syncytial virus (RSV) F-protein nanoparticle vaccine was undertaken in 4,636 pregnant women and their infants. RSV F-protein vaccine was safe and immunogenic in the pregnant women inducing anti-F IgG, palivizumab-competing antibodies and RSV neutralizing antibodies that were transferred to the fetus.
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Associations of prenatal alcohol exposure and offspring harmful alcohol use: findings from the Raine StudyEpidemiological evidence suggests offspring exposed to prenatal alcohol are at increased risk of alcohol use disorders in adulthood. The evidence on the risk of developing harmful alcohol use in adolescence is less clear.
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CASSETTE-clindamycin adjunctive therapy for severe Staphylococcus aureus treatment evaluation: Study protocol for a randomised controlled trialThis study will assess the effect of adjunctive clindamycin on patient-centred outcomes in severe, toxin-mediated S. aureus infections
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Does otitis media in early childhood affect later behavioural development? Results from the Western Australian Pregnancy Cohort (Raine) StudyThe relationship between early life episodes of otitis media and later behavioural development with adjustment for confounders.
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Moraxella catarrhalis Restriction-Modification Systems Are Associated with Phylogenetic Lineage and DiseaseWe observed an association between Type III DNA methyltransferase presence and Otitis Media-associated middle ear isolates
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Rheumatic Heart Disease Worldwide: JACC Scientific Expert PanelThe authors present a variety of pressing clinical research questions on optimal RHD prevention and advanced care
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Worldwide variation in human milk metabolome: Indicators of breast physiology and maternal lifestyle?This study investigates the variation of human milk metabolites in human milk between five different countries
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The Canmore Declaration: Statement of Principles for Planetary HealthWe provide the Canmore Declaration, a Statement of Principles for Planetary Health
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IgE and T-cell responses to house dust mite allergen componentsRecent studies with synthetic peptides representing allergens and non-allergenic house dust mite proteins now offer new research avenues on HDM induced immune responses
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Epigenetic dysregulation of naive CD4+ T-cell activation genes in childhood food allergyOur data indicate epigenetic dysregulation in the early stages of signal transduction through the T cell receptor complex, and likely reflects pathways modified by gene-environment interactions in food allergy