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Temporally restricted activation of IFNβ signaling determines response to immune checkpoint therapyThe biological determinants of the response to immune checkpoint blockade (ICB) in cancer remain incompletely understood. Little is known about dynamic biological events that underpin therapeutic efficacy due to the inability to frequently sample tumours in patients.
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CD4+ T cells drive an inflammatory, TNF-α/IFN-rich tumor microenvironment responsive to chemotherapyWhile chemotherapy remains the first-line treatment for many cancers, it is still unclear what distinguishes responders from non-responders. Here, we characterize the chemotherapy-responsive tumor microenvironment in mice, using RNA sequencing on tumors before and after cyclophosphamide, and compare the gene expression profiles of responders with progressors.
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Cerebral palsy and perinatal mortality after pregnancy-induced hypertension across the gestational age spectrum: Observations of a reconstructed total population cohortThis reconstructed total population cohort paper investigates the relationship between cerebral palsy & pregnancy induced hypertension.
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Folate status in Aboriginal people before and after mandatory fortification of flour for bread-making in AustraliaThe mandatory fortification of wheat flour for bread-making has increased folate status and reduced Neural Tube Defects in the Australian Aboriginal population
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Autonomic nervous system dysfunction in psychiatric disorders and the impact of psychotropic medications: A systematic review and meta-analysisFindings confirm substantial reductions in heart rate variability across psychiatric disorders, and remained significant even in medication-free individuals
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Prevention of Insulin-Induced Hypoglycemia in Type 1 Diabetes with Predictive Low Glucose Management SystemThe aim of this study was to determine whether predictive low glucose management (PLGM) system is effective in preventing insulin-induced hypoglycemia
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Interferon regulatory factor 7 regulates airway epithelial cell responses to human rhinovirus infectionIRF7 regulates the expression of genes involved in antiviral immunity, inflammation, and the response to oxidative stress during HRV infections in HBE cells
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Heat-mediated reduction of apoptosis in UVB-damaged keratinocytes in vitro and in human skin ex vivoUVB-induced p53-mediated cell cycle arrest and apoptosis are reduced in the presence of heat stress, leading to increased survival of DNA damaged cells
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School policies on bullying and cyberbullying: perspectives across three Australian statesThe perspectives of professionals involved in bullying and cyberbullying policy construction, across three different Australian states
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ViPAR: A software platform for the Virtual Pooling and Analysis of Research DataViPAR is a secure, flexible and powerful analysis platform built on open source technology that is currently in use by large international consortia