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Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphomaIL7 and glucocorticoids coordinately drive aberrant activation of PIM1 and suggests that T-ALL and T-LBL patients could benefit from PIM inhibition
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Germline Elongator mutations in Sonic Hedgehog medulloblastomaGenetic predisposition to proteome instability may be a determinant in the pathogenesis of paediatric brain cancers
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Advances in Exercise, Physical Activity, and DiabetesWe screened more than 750 potentially eligible titles on PubMed and other common search engines for manuscripts on “exercise and diabetes”
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The effect of upgrades to childcare outdoor spaces on preschoolers’ physical activity: Findings from a natural experimentThis natural experiment investigated the influence of early childhood education and care outdoor physical environment upgrade on preschoolers' physical activity
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Higher frequency of vertebrate-infecting viruses in the gut of infants born to mothers with type 1 diabetesWe demonstrate a distinct gut virome profile in infants of mothers with type 1 diabetes, which may influence health outcomes later in life
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Misgendering and experiences of stigma within health care settings for transgender individualsMisgendering within the health care system can significantly affect the mental and physical health of transgender individuals
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Content validation of the Quality of Life Inventory—DisabilitySatisfactory content validity is reported, where ongoing consumer feedback shaped the dataset from which the final items were selected
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Spaceship earth revisited: The co‐benefits of overcoming biological extinction of experience at the level of person, place and planetThis commentary focuses the ways in which microbes, as an essential part of all ecosystems, provide a vital link between personal and planetary systems
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Choosing primary endpoints for clinical trials of health care interventionsThis narrative review describes the evolution, range and relative strengths and weaknesses of endpoints used in late phase trials
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Requirements for improving health and well-being of children with Prader-Willi syndrome and their familiesPrader-Willi syndrome (PWS) is a rare genetic condition with multi-system involvement