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Research

Lipidomics reveals associations of phospholipids with obesity and insulin resistance in young adults

Lipidomic biomarkers associated with obesity and IR using plasma samples from a population-based cohort of young adults

Research

Reduced heart rate variability in remitted bipolar disorder and recurrent depression

Heart Rate Variability was found to be lower in the bipolar and depression groups, compared with control subjects

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Multiple risk exposures for reading achievement in childhood and adolescence

Across 6 years of school, multiple risk-exposed children lagged behind low risk-exposed children in the order of years of lost gains in reading achievement

Research

Bronchodilator responsiveness in children with asthma is not influenced by spacer device selection

Spacer device was not associated with clinically important differences in lung function following bronchodilator inhalation in children with asthma

Research

Risk factors and prognosis of recurrent wheezing in Chinese young children: A prospective cohort study

We aimed to investigate the risk factors for different wheezing phenotypes in Chinese young children and to explore the prognosis of recurrent wheezing

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The controlled direct effect of temperament at 2-3 years on cognitive and academic outcomes at 6-7 years

Overall, temperament had small associations with cognitive and academic outcomes after accounting for parenting and confounders

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Tricho-hepatic-enteric syndrome (THES) without intractable diarrhoea

We report an 8 year old girl who was diagnosed with THES by the Undiagnosed Disease Program-WA with compound heterozygous pathogenic variants in SKIV2L

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Upper Airway Cell Transcriptomics Identify a Major New Immunological Phenotype with Strong Clinical Correlates in Young Children with Acute Wheezing

Asthma exacerbations in children can be divided into IRF7hi versus IRF7lo phenotypes with associated differences in clinical phenotypes

Research

Concurrent developmental course of sleep problems and emotional/behavioral problems in childhood and adolescence as reflected by the dysregulation profile

Findings provide evidence for a strong association in the development of sleep problems and difficulties of dysregulation with emotion, cognition, and aggression

Research

Epigenome-wide meta-analysis of DNA methylation and childhood asthma

Novel loci differentially methylated in newborns represent potential biomarkers of risk of asthma by school age