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Research
Is forced oscillation technique the next respiratory function test of choice in childhood asthmaWhile spirometry contributes to asthma diagnosis and management in older children, it has a limited role in younger children whom are unable to perform FOM.
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Premedication with salbutamol prior to surgery does not decrease the risk of perioperative respiratory adverse events in school-aged childrenPremedication with salbutamol to children prior to their surgery did not reduce their risk of Perioperative respiratory adverse events
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An Official ATS/ERS Workshop Report: Evaluation of Respiratory Mechanics and Function in the Pediatric and Neonatal Intensive Care UnitsThis report summarizes techniques available for ventilated and spontaneously breathing infants and children in the ICU
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Defining the appropriate waiting time between multiple-breath nitrogen washout measurementsThis letter addresses the recommendations by the American Thoracic Society & European Respiratory Society in 2005, that patients must wait 15-60mins between...
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Effects of adopting the new global lung function initiative 2012 reference equations on the interpretation of spirometryThe aim of this study was to document the likely interpretative effects of changing from commonly used current spirometry reference equations to the GLI2012...
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Novel end points for clinical trials in young children with cystic fibrosisCystic fibrosis (CF) lung disease commences early in the disease progression and is the most common cause of mortality.
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Early detection of lung function abnormalities in young children with cystic fibrosisIn this review, we have examined the role of lung function testing in infants and preschool children with CF.
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Health service utilisation for acute respiratory infections in infants graduating from the neonatal intensive care unit: a population-based cohort studyDespite advances in neonatal intensive care, babies admitted to Neonatal Intensive Care Units (NICU) suffer from adverse outcomes. We aim to describe the longer-term respiratory infectious morbidity of infants discharged from NICU using state-wide population-based linked data in Western Australia.
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Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease riskLung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age and smoking groups, and collectively as a genetic risk score showed strong association with COPD across ancestry groups.
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Early life exposure to coal mine fire smoke emissions and altered lung function in young childrenInfant exposure to coal mine fire emissions could be associated with long-term impairment of lung reactance