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Genetics, Transcriptomics and Meta-Taxonomics in Visceral LeishmaniasisVisceral leishmaniasis (VL) caused by parasites of the Leishmania donovani complex can be fatal in susceptible individuals. Understanding the interactions between host and pathogen is one way to obtain leads to develop better drugs and for vaccine development. In recent years multiple omics-based approaches have assisted researchers to gain a more global picture of this interaction in leishmaniasis. Here we review results from studies using three omics-based approaches to study VL caused by L. donovani in India.
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Arylsulphatase A Pseudodeficiency (ARSA-PD), hypertension and chronic renal disease in Aboriginal AustraliansTraits associated with CVD, CRD and T2D in Aboriginal Australians provide novel insight into function of Arylsulphatase A Pseudodeficiency variants
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Association between male genital anomalies and adult male reproductive disorders: a population-based data linkage study spanning more than 40 yearsWe provide new evidence to support current guidelines for orchidopexy before age 18 months to decrease the risk of future testicular cancer and infertility
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Maternal and umbilical cord androgen concentrations do not predict digit ratio (2D:4D) in girls:Digit ratio (2D:4D) is widely used as a marker of prenatal androgen exposure
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The -2518bp promoter polymorphism at CCL2/MCP1 influences susceptibility to mucosal but not localizedMucosal leishmaniasis (ML) follows localized cutaneous leishmaniasis (CL) caused by Leishmania braziliensis.
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Cytokine Responses to Novel Antigens in an Indian Population Living in an Area Endemic for Visceral LeishmaniasisHere we employ whole blood assays to evaluate human cytokine responses to 11 of these antigens, in comparison to known defined and crude antigen preparations.
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Genetic Research and Aboriginal and Torres Strait Islander AustraliansHuman genetic research promises to deliver a range of health benefits to the population. Here we consider how the different levels of Indigenous research...
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Prevalence and risk factors for parent-reported recurrent otitis media during early childhoodThe prevalence of parent-reported rOM was 26.8% (611/2280) and 5.5% (125/2280) for severe rOM in the Study.
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Prevalence and risk factors for parent-reported recurrent otitis media during early childhoodThe objective was to describe the prevalence and risk factors of recurrent otitis media (rOM) in an urban Australian population at 3 years of age.
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The -308 bp TNF gene polymorphism influences tumor necrosis factor expression in leprosy patients in Bahia State, BrazilTNF mRNA expression was higher in leprosy patients compared to endemic controls, but did not differ significantly between clinical subgroups