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Respiratory infection and wheezing illness are leading causes of hospitalisation in childhood, placing a significant burden on families and healthcare systems. However, reliably distinguishing children at risk of developing persistent disease from those likely to outgrow their symptoms remains a clinical challenge. Earlier identification would allow clinicians to focus care and resources on those most likely to benefit from long-term management, while reducing anxiety and uncertainty about the future for families.
To introduce a disease prognosis framework enabled by a robust classification scheme derived from patient-specific transcriptomic response to stimulation.
This study demonstrates novel intrinsic differences in tight junctions gene and protein expression between airway epithelial cells of children with and without asthma
Data indicate a role for Interferonβ in linking viral infection and allergy
The aim of this study was to longitudinally assess the prevalence of allergic sensitization, asthma, eczema and hay fever from infancy to adulthood
Our findings suggest that the proportion of degranulated basophils can also be associated with recurrent exacerbations
Airway interleukin-33 is associated with type-2 cytokines in naturally occurring asthma exacerbations in adults
We aimed to research relationships between 25(OH)D levels from birth to 10 y/o and susceptibility to allergic sensitization, respiratory issues and asthma.
Type 2 inflammation is present in patients during virus-induced asthma exacerbations, to the same degree as non-viral exacerbations
Eosinophilic asthma exacerbations may be clinically more severe than non-eosinophilic exacerbation