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Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4Previous genome-wide association studies revealed multiple common variants involved in eczema but the role of rare variants remains to be elucidated. Here, we investigate the role of rare variants in eczema susceptibility. We meta-analyze 21 study populations including 20,016 eczema cases and 380,433 controls. Rare variants are imputed with high accuracy using large population-based reference panels.
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Traffic exposure, air pollution and children's physical activity at early childhood education and careA significant number of children attend Early Childhood Education and Care (ECEC). ECEC is an important environment and behaviour setting for young children. Time spent outdoors is positively associated with children's physical activity levels, yet increased time spent physically active outdoors may expose young children to traffic-related air pollution, particularly in ECEC centres located in high traffic areas.
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Methods for modelling excess mortality across England during the COVID-19 pandemicExcess mortality is an important measure of the scale of the coronavirus-2019 pandemic. It includes both deaths caused directly by the pandemic, and deaths caused by the unintended consequences of containment such as delays to accessing care or postponements of healthcare provision in the population. In 2020 and 2021, in England, multiple groups have produced measures of excess mortality during the pandemic.
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Revision of the Australian guidelines to reduce health risks from drinking alcoholThe Australian guidelines to reduce health risks from drinking alcohol were released in 2020 by the National Health and Medical Research Council. Based on the latest evidence, the guidelines provide advice on how to keep the risk of harm from alcohol low.
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Standardising and assessing digital images for use in clinical trials: A practical, reproducible method that blinds the assessor to treatment allocationWe describe the development and evaluation of a protocol for digital image collection by the non-professional photographer in a remote setting research trial
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Gene Expression Analyses of the Spatio-Temporal Relationships of Human Medulloblastoma Subgroups during Early Human NeurogenesisMedulloblastoma is the most common form of malignant paediatric brain tumour and is the leading cause of childhood cancer related mortality.
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Plasma retinol and total carotenes and fracture risk after long-term supplementation with high doses of retinolThe aim of this study was to investigate plasma retinol and total carotene concentrations in relation to fracture risk after long-term supplementation with...
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What do infectious diseases physicians do? A 2-week snapshot of inpatient consultative activities across Australia, New Zealand and SingaporeWe performed a 2-week prospective survey of formal ID physician activities related to direct inpatient care, encompassing 53 hospitals throughout Australia,...
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Young Aboriginal women's voices on pregnancy care: Factors encouraging antenatal engagementUnderstanding young Aboriginal women's views on pregnancy care is important knowledge to assist maternity services develop localised pathways that encourage...
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Parents' nonstandard work schedules and child well-being: A critical review of the literatureThis paper provides a comprehensive review of empirical evidence linking parental nonstandard work schedules to four main child developmental outcomes:...