Search
Research
Intrauterine Growth Restriction Promotes Postnatal Airway Hyperresponsiveness Independent of Allergic DiseaseIntrauterine growth restriction (IUGR) is associated with asthma. Murine models of IUGR have altered airway responsiveness in the absence of any inflammatory exposure. Given that a primary feature of asthma is airway inflammation, IUGR-affected individuals may develop more substantial respiratory impairment if subsequently exposed to an allergen. This study used a maternal hypoxia-induced mouse model of IUGR to determine the combined effects of IUGR and allergy on airway responsiveness.
Research
Identification of genes differentially regulated by vitamin D deficiency that alter lung pathophysiology and inflammation in allergic airways diseaseVitamin D deficiency exacerbates house dust mite-induced inflammation and alterations in lung structure and function
Research
Immunodominant T-cell epitopes in the VP1 capsid protein of rhinovirus species A and COur results indicate a dissociation between the antibody and T-cell responses to rhinoviruses
Research
Reduced transforming growth factor β1 (TGF-β1) in the repair of airway epithelial cells of children with asthmaEvidence into the role of TGF-β1 in airway epithelial repair in asthma is still controversial. This study tested the hypothesis that the reduced TGF-β1 levels previously observed in paediatric asthmatic airway epithelial cells directly contribute to the dysregulated repair seen in these cells.
Research
Analysis of IgE binding patterns to house dust mite allergens in scabies-endemic communities: insights for both diseasesThis study analysed the IgE binding patterns caused by house dust mite allergens in scabies endemic communities in Australia.
Research
Severe winter asthma exacerbations can be prevented by omalizumab, but there is no carryover effect.Recurrent severe asthma exacerbations are associated with decreased lung growth or accelerated loss of long function and add substantially to cost and morbidity
Research
Genome-wide association study of IgG1 responses to the choline-binding protein PspC of Streptococcus pneumoniaeDelayed development of antibodies to S. pneumoniae in infancy is associated with the development of atopy and asthma.
Research
The effects of e-cigarette use on asthma severity in adult BALB/c miceElectronic cigarettes (e-cigarettes) are often perceived to be a less harmful alternative to tobacco cigarettes. Potentially due to this perception, they are used by people with pre-existing respiratory conditions, such as asthma, who otherwise would not smoke. Despite this, there are few studies exploring the health effects of e-cigarette use on pre-existing asthma.
Research
Editorial: The relationship between puberty and immune-driven diseaseThe way the immune system operates differs between males and females. This is due to both differential expression of immune-related genes from the sex chromosomes as well as the immune modulatory properties of sex hormones. Together, these effects contribute to a skewed prevalence of disease and disease course between males and females, including allergic-, infectious-, autoimmune-, and cancerous disease.
Research
BCG-Induced Immune Training: Interplay between Trained Immunity and Emergency GranulopoiesisBacille Calmette-Guérin (BCG) is the most commonly administered vaccine in human history. The medical application of BCG extends far beyond the fight against tuberculosis. Despite its stellar medical record over 100 years, insight into how BCG provides this vast range of benefits is largely limited, both for its pathogen-specific (tuberculosis) as well as pathogen-agnostic (other infections, autoimmunity, allergies, and cancer) effects.