Search
Research
Airway-associated adipose tissue accumulation is increased in a kisspeptin receptor knockout mouse modelAirway-associated adipose tissue increases with body mass index and is a local source of pro-inflammatory adipokines that may contribute to airway pathology in asthma co-existing with obesity. Genetic susceptibility to airway adiposity was considered in the present study through kisspeptin/kisspeptin receptor signalling, known to modulate systemic adiposity and potentially drive airway remodelling.
Research
Editorial: The relationship between puberty and immune-driven diseaseThe way the immune system operates differs between males and females. This is due to both differential expression of immune-related genes from the sex chromosomes as well as the immune modulatory properties of sex hormones. Together, these effects contribute to a skewed prevalence of disease and disease course between males and females, including allergic-, infectious-, autoimmune-, and cancerous disease.
Research
BCG-Induced Immune Training: Interplay between Trained Immunity and Emergency GranulopoiesisBacille Calmette-Guérin (BCG) is the most commonly administered vaccine in human history. The medical application of BCG extends far beyond the fight against tuberculosis. Despite its stellar medical record over 100 years, insight into how BCG provides this vast range of benefits is largely limited, both for its pathogen-specific (tuberculosis) as well as pathogen-agnostic (other infections, autoimmunity, allergies, and cancer) effects.
Research
Identifying the asthma research priorities of people with asthma, their carers and other stakeholdersPeople living with asthma, their carers, clinicians and policymakers are the end-users of research and need research that address their individual healthcare needs. We aimed to understand the research priorities of end-users of asthma research.
Research
Intrauterine Growth Restriction Promotes Postnatal Airway Hyperresponsiveness Independent of Allergic DiseaseIntrauterine growth restriction (IUGR) is associated with asthma. Murine models of IUGR have altered airway responsiveness in the absence of any inflammatory exposure. Given that a primary feature of asthma is airway inflammation, IUGR-affected individuals may develop more substantial respiratory impairment if subsequently exposed to an allergen. This study used a maternal hypoxia-induced mouse model of IUGR to determine the combined effects of IUGR and allergy on airway responsiveness.
Research
Severe winter asthma exacerbations can be prevented by omalizumab, but there is no carryover effect.Recurrent severe asthma exacerbations are associated with decreased lung growth or accelerated loss of long function and add substantially to cost and morbidity
Research
Immunodominant T-cell epitopes in the VP1 capsid protein of rhinovirus species A and COur results indicate a dissociation between the antibody and T-cell responses to rhinoviruses
Research
Lower anti-echovirus antibody responses in children presenting to hospital with asthma exacerbations.This article assesses the absolute and specific antibody titres to VP1 antigens of the gut-trophic enteroviruses, echovirus 30 and Sabin 1 poliovirus, in...
Research
Genome-wide association study of IgG1 responses to the choline-binding protein PspC of Streptococcus pneumoniaeDelayed development of antibodies to S. pneumoniae in infancy is associated with the development of atopy and asthma.
Research
Infant respiratory infections and later respiratory hospitalisation in childhoodThe aim of this study was to use total-population based data on an otherwise healthy population of children to assess the relationship between early...