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Angiogenesis-associated pathways play critical roles in neonatal sepsis outcomesNeonatal sepsis is a major cause of childhood mortality. Limited diagnostic tools and mechanistic insights have hampered our abilities to develop prophylactic or therapeutic interventions. Biomarkers in human neonatal sepsis have been repeatedly identified as associated with dysregulation of angiopoietin signaling and altered arachidonic acid metabolism.
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Supporting best practice in the management of chronic diseases in primary health care settings: a scoping review of training programs for Indigenous Health Workers and PractitionersTo improve diabetes management in primary health care for the Aboriginal and Torres Strait Islander peoples population, training programs that are culturally and contextually relevant to the local context are required. Using a scoping review methodology, the aim of this review was to describe the characteristics of chronic disease management training programs for Aboriginal Health Workers and Practitioners, their effectiveness on knowledge and skills, and client-related outcomes, and the enablers, barriers to delivery and participation.
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How can we reach long-lasting inclusive participation for all? A vision for the futureIn 2022, an international conference was held focusing on 'participation'. We shared current evidence, identified knowledge gaps and worked together to understand what new knowledge and community and practice changes were needed. This brief communication is a summary of the conference delegates' discussions.
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Adipose tissue in the small airways: How much is enough to drive functional changes?Obesity is a contributing factor to asthma severity; while it has long been understood that obesity is related to greater asthma burden, the mechanisms though which this occurs have not been fully elucidated. One common explanation is that obesity mechanically reduces lung volume through accumulation of adipose tissue external to the thoracic cavity.
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Neonatal outcomes after preterm birth by mothers' health insurance status at birth: a retrospective cohort studyPublicly insured women usually have a different demographic background to privately insured women, which is related to poor neonatal outcomes after birth.
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Role of public and private funding in the rising caesarean section rate: A cohort studyOur results indicate that an increase in the prelabour caesarean delivery rate for private patients in private hospitals has been driving the increase in the...
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Autism spectrum disorder in children born preterm: Role of exposure to perinatal inflammationThis review aims to summarise and evaluate the potential mechanisms and evidence for the role of prenatal infection on the central nervous system, and how it...
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Dental admissions in children under two years - A total-population investigationThis paper describes dental and oral cavity admissions and associated factors in children under two years of age using total-population databases.
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A phase 2 open-label safety and immunogenicity study of a meningococcal B bivalent rLP2086 vaccine in healthy adultsNo currently licensed and available vaccine has been shown to provide broad protection against endemic MnB disease.
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No dose-dependent increase in fracture risk after long-term exposure to high doses of retinol or beta-caroteneThis intervention study found no increase in fracture risk among 2,322 adults who took a controlled, high-dose retinol supplement (25,000 IU retinyl...