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In Epigenomic Studies, Including Cell-Type Adjustments in Regression Models Can Introduce Multicollinearity, Resulting in Apparent Reversal of Direction of AssociationWhere cell types are highly correlated with other covariates in regression models, the statistical assumption of no multicollinearity may be violated
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Maternal Smoking During Pregnancy Induces Epigenetic Changes Into Adolescence, Independent of Postnatal Smoke Exposure and Is Associated With Cardiometabolic RiskThis study demonstrates a critical timing of cigarette smoke exposure over the life course for establishing persistent changes in DNA methylation into adolescence
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Real-world outcomes of insulin pump compared to injection therapy in a population-based sample of children with type 1 diabetesPatients using insulin pump therapy had a better long-term glycemic control relative to the matched injection therapy cohort
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Effect of obesity on neonatal hypoglycaemia in mothers with gestational diabetes: A comparative studyTo determine the influence of obesity on neonatal hypoglycaemia among infants born to gestational diabetes mellitus mothers.
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Clinical and demographic risk factors associated with mortality during early adulthood in a population-based cohort of childhood-onset Type 1 diabetesThis paper reports calculated standardized mortality ratios in patients with Type 1 diabetes, and assesses the association between poor management of...
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Prevention of Insulin-Induced Hypoglycemia in Type 1 Diabetes with Predictive Low Glucose Management SystemThe aim of this study was to determine whether predictive low glucose management (PLGM) system is effective in preventing insulin-induced hypoglycemia
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Glycaemic control of Type 1 diabetes in clinical practice early in the 21st century: An international comparisonImproving glycaemic control in people with Type 1 diabetes is known to reduce complications.
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Effect of antecedent moderate-intensity exercise on the glycemia-increasing effect of a 30-sec maximal sprint: a sex comparisonThis study investigated whether a prior bout of moderate-intensity exercise attenuates the glycemia-increasing effect of a maximal 30-sec sprint.
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Regular peaks and troughs in the Australian incidence of childhood type 1 diabetes mellitus (2000–2011).This study aimed to determine the incidence and incidence rate trends of type 1 diabetes mellitus in children aged 0–14 years...
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Adiposity associated DNA methylation signatures in adolescents are related to leptin and perinatal factorsEpigenetics links perinatal influences with later obesity. We identifed differentially methylated CpG (dmCpG) loci measured at 17 years associated with concurrent adiposity measures and examined whether these were associated with hsCRP, adipokines, and early life environmental factors. Genome-wide DNA methylation from 1192 Raine Study participants at 17 years, identified 29 dmCpGs associated with body mass index, 10 with waist circumference and 9 with subcutaneous fat thickness.