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Preschool Multiple-Breath Washout Testing. An Official American Thoracic Society Technical StatementConsensus recommendations are outlined to direct preschool device design, test performance, and data analysis for the MBW technique
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Determinants of early-life lung function in African infantsTo assess the determinants of early lung function in African infants.
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Early lung disease in infants and preschool children with cystic fibrosis: What have we learned and what should we do about it?This review summarizes what we have learned about early lung disease in children with CF and discusses the implications for clinical practice and research
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Investigating the relationship between environmental factors and respiratory health outcomes in school children using the forced oscillation techniqueThe significance of both indoor and outdoor sources of air pollution and effect modifiers such as green space and heating require further investigation
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Epidural insertion height for ureteric reimplant surgery; does location matter?The caudal catheter technique was superior at reducing pain interventions, particularly bladder spasm interventions
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The association between Staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosisDe novo S. aureus acquisition at age 3 is associated with later bronchiectasis and FEF25-75 in children with CF
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Smoking during pregnancy, vitamin C supplementation, and infant respiratory healthThis article discusses the merits and potential shortcomings of a study reported previously showing that giving Vitamin C to women who smoked during...
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Transcriptomic analysis of primary nasal epithelial cells reveals altered interferon signalling in preterm birth survivors at one year of ageMany survivors of preterm birth (<37 weeks gestation) have lifelong respiratory deficits, the drivers of which remain unknown. Influencers of pathophysiological outcomes are often detectable at the gene level and pinpointing these differences can help guide targeted research and interventions. This study provides the first transcriptomic analysis of primary nasal airway epithelial cells in survivors of preterm birth at approximately 1 year of age.
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Inhaled corticosteroids to improve lung function in children (aged 6–12 years) who were born very preterm (PICSI): a randomised, double-blind, placebo-controlled trialDespite the substantial burden of lung disease throughout childhood in children who were born very preterm, there are no evidence-based interventions to improve lung health beyond the neonatal period. We tested the hypothesis that inhaled corticosteroid improves lung function in this population.
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The ventilatory response to hypoxia is blunted in some preterm infants during the second year of lifePreterm birth and subsequent neonatal ventilatory treatment disrupts development of the hypoxic ventilatory response (HVR). An attenuated HVR has been identified in preterm neonates, however it is unknown whether the attenuation persists into the second year of life.