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Population-based birth cohorts on asthma and allergies increasingly provide new insights into the development and natural history of the diseases.
Asthma is a chronic disease of the airways, most commonly driven by immuno-inflammatory responses to ubiquitous airborne antigens.
There is evidence to suggest an association between prenatal maternal stress and the development of asthma or other atopic diseases in offspring.
Sex-related differences in bronchial hyperresponsiveness (BHR) have been reported in adolescents, but the mechanisms remain obscure.
The airway epithelium forms a highly regulated physical barrier that normally prevents invasion of inhaled pathogens and allergens from the airway lumen.
The aim of this study was to explore associations between severe respiratory infections and atopy in early childhood with persisting wheeze and asthma.
Interleukin-10 is a key immunomodulatory cytokine the principal function of which is to limit the magnitude of immune response.
When the allergen nomenclature system was adopted in 1986, allergens were identified by their behavior on electrophoresis and chromatography...
The hallmark of atopic asthma is transient airways hyperresponsiveness (AHR) preceded by aeroallergen-induced Th-cell activation.
Childhood asthma is a condition characterized by airflow obstruction that varies in time spontaneously, in response to various environmental stimuli...