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Research
Targeting the bone marrow microenvironment: a novel therapeutic strategy for pre-B acute lymphoblastic leukemiaOur findings shed light on the mechanisms of leukemia-induced bone loss
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A large proportion of poor birth outcomes among Aboriginal Western Australians are attributable to smoking, alcohol and substance misuse, and assaultA large proportion of adverse outcomes were attributable to the modifiable risk factors of substance use and assault
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Atypical nested 22q11.2 duplications are associated with neurodevelopmental phenotypes including autism spectrum disorder with incomplete penetranceOur findings contribute to the genotype–phenotype data for atypical nested 22q11.2 duplications, with implications for genetic counseling
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Research priorities for childhood chronic conditions: a workshop reportResearch priorities emphasise a focus on life participation, psychosocial well-being, impact on family and quality of care
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Persistent negative symptoms in individuals at Ultra High Risk for psychosisPersistent negative symptoms can be detected early, allowing for the identification of a subset of Ultra High Risk patients who are likely to have poor outcome
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Effectiveness of pneumococcal conjugate vaccine against hospital admissions for pneumonia in Australian childrenReductions in pneumonia-coded hospital admissions in unvaccinated children predominated in non-Aboriginal children with low incidence of pneumonia
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A Survey of Infectious Diseases and Microbiology Clinicians in Australia and New Zealand About the Management of Staphylococcus aureus BacteremiaSignificant variation in practice, particularly for patients with a severe disease phenotype and antibiotic-resistant profile
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High concentrations of middle ear antimicrobial peptides and proteins are associated with detection of middle ear pathogens in children with recurrent acute otitis mediaElevated antimicrobial proteins and peptides and cytokines in middle ear effusion are a marker of inflammation and bacterial persistence
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Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomicsWe identified the existence of more than 290 clinically associated genomic phylogroups across 22 countries, highlighting challenges in designing vaccines of global utility
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Vitamin and mineral supplements: Gut health and probiotics: Probiotics for a healthy microbiome: An evidence-based approach to appropriate product choiceThis review discusses the available evidence base to help provide practical guidance when considering probiotics in practice