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Research

Assessment of early lung disease in young children with CF: A comparison between pressure-controlled and free-breathing chest computed tomography

Our data suggest that FRC PC-CTs are less sensitive than TLC PC-CTs and that FB-CTs have similar sensitivity to PC-CTs in detecting lung disease

Research

The Undiagnosed Diseases Network International: Five years and more

The Undiagnosed Diseases Network International was established with the major aims of providing diagnoses to patients

Research

Very Early Identification and Intervention for Infants at Risk of Neurodevelopmental Disorders: A Transdiagnostic Approach

In this article, we examine the utility of a transdiagnostic, dimensional approach to very early identification and intervention for infants at risk of neurodevelopmental disorders

Research

Understanding group A streptococcal pharyngitis and skin infections as causes of rheumatic fever: Protocol for a prospective disease incidence study

This study will identify the incidence of true Group A Streptococcal pharyngitis and serological responses to Group A Streptococcal GAS skin infections

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Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics

We identified the existence of more than 290 clinically associated genomic phylogroups across 22 countries, highlighting challenges in designing vaccines of global utility

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RD-RAP: Beyond rare disease patient registries, devising a comprehensive data and analytic framework

We introduce and describe the concept of a Rare Disease Registry and Analytics Platform

Research

Vitamin and mineral supplements: Gut health and probiotics: Probiotics for a healthy microbiome: An evidence-based approach to appropriate product choice

This review discusses the available evidence base to help provide practical guidance when considering probiotics in practice

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No detectable effects of acute tryptophan depletion on short-term immune system cytokine levels in healthy adults

The acute tryptophan depletion condition did not result in significant changes to cytokine concentrations for the entire study sample

Research

Community-based participatory action research on rheumatic heart disease in an Australian Aboriginal homeland: Evaluation of the ‘On track watch’ project

Based in 'both-way learning', the aim of this study was to co-design, implement and evaluate community-based participatory action research to achieve this vision