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Acinar ventilation inhomogeneity measured by single-breath washout was not associated with structural lung disease on CT

Structural changes identified on CT scans in primary ciliary dyskinesia are not identical to those previously described in cystic fibrosis patients

Protease elastase exocytosis by airway neutrophils occurs in all cystic fibrosis children, and its cellular measure correlates with early lung damage

Our data associates IL-1α with early structural lung damage in CF and suggests this pathway as a novel anti-inflammatory target

This study demonstrates the feasibility of utilizing pre-clinical in vitro culture models to screen therapeutic candidates

Whether airway mucosal acidification drives early progressive lung disease is controversial

De novo S. aureus acquisition at age 3 is associated with later bronchiectasis and FEF25-75 in children with CF

We characterized the lower airways microbiome using BAL samples obtained from clinically stable CF young children who underwent bronchoscopy and chest CT.

Our findings provide new insight into the molecular mechanisms operative at baseline in the airway mucosa in atopic asthmatic with natural aeroallergen exposure

Background: We assessed the effect of posture on ventilation distribution and the impact on associations with structural lung disease.