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Three Pseudomonas sp. strains isolated from marine sponges have shown potential quorum sensing inhibition activity

Chest CT identifies children at an early age who have adverse long-term outcomes

Vibrio hibernica is capable of metabolizing a unique carbohydrate profile at low temperatures

Aspergillus species and P. aeruginosa are commonly present in the lower airways from infancy

Adaptive variants of P. aeruginosa that arise following long term bile exposure enables the emergence of ecologically competitive sub-populations

Acinar ventilation inhomogeneity measured by single-breath washout was not associated with structural lung disease on CT

Structural changes identified on CT scans in primary ciliary dyskinesia are not identical to those previously described in cystic fibrosis patients

Protease elastase exocytosis by airway neutrophils occurs in all cystic fibrosis children, and its cellular measure correlates with early lung damage

Our data associates IL-1α with early structural lung damage in CF and suggests this pathway as a novel anti-inflammatory target

This study demonstrates the feasibility of utilizing pre-clinical in vitro culture models to screen therapeutic candidates