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Research
Immunogenicity and clinical effectiveness of the trivalent inactivated influenza vaccine in immunocompromised children undergoing treatment for cancerThe trivalent inactivated influenza vaccine is safe, immunogenic, provides clinical protection and should be administered annually to immunosuppressed children receiving treatment for cancer

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Inklings at CliniKidsInklings is a new program for babies aged 6-18 months who are showing early differences in their social interaction and communication development.
Research
Medulloblastoma therapy generates risk of a poorly-prognostic H3 wild-type subgroup of diffuse intrinsic pontine glioma: a report from the International DIPG RegistryThese findings provide a compelling argument for efforts to reduce exposure of the brainstem in the treatment of medulloblastoma
Research
Diffuse Intrinsic Pontine GliomaThis chapter summarizes recent advances in diffuse intrinsic pontine glioma and potential novel therapies
Research
Pediatric meningioma: Current approaches and future directionWith improvement in leukemia therapy, central nervous system (CNS) tumors are the leading cause of cancer mortality in children and the most expensive...

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Joondalup clinic updateOur new Joondalup clinic opened in late September and has been firing on all cylinders ever since. CliniKids Joondalup has welcomed about 40 new families into the service since opening, with approximately 52 therapy and research appointments scheduled weekly onsite.
Research
Cyclophosphamide chemotherapy sensitizes tumor cells to TRAIL-dependent CD8 T cell-mediated immune attack resulting in suppression of tumor growthAnti-cancer chemotherapy can be simultaneously lymphodepleting and immunostimulatory.
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Novel peptide-based drugs for the treatment of sonic hedgehog-dependent medulloblastomaMedulloblastoma, the most common pediatric malignant brain tumor, consists of at least four distinct molecular subgroups.
Research
Vehicle refuelling, use of domestic wood heaters and the risk of childhood brain tumours: Results from an Australian case-control studyThe aetiology of childhood brain tumours (CBT) is largely unknown.

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Clinic shutdown datesPlease note that both the Subiaco and Joondalup clinics will shut down for the Christmas and New Year period from Friday, December 23, through to Wednesday, January 4, inclusive. The clinics will re-open on Thursday, January 5, 2023.
Research
Aberrant expression of aldehyde dehydrogenase 1A (ALDH1A) subfamily genes in acute lymphoblastic leukaemia is a common feature of T-lineage tumoursThe class 1A aldehyde dehydrogenase (ALDH1A) subfamily of genes encode enzymes that function at the apex of the retinoic acid (RA) signalling pathway.
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Chemotherapy increases amenability of surgical resection in congenital glioblastomaBrain tumors presenting in infancy, especially during the first 6 months of life.
Research
Participation in paediatric cancer studies: Timing and approach to recruitmentIn this sub-study, we aimed to investigate factors that may have influenced study participation and completeness of survey completion.

News & Events
New team members!CliniKids recently welcomed Gayle, Tarryn and Emma to the clinical team. The clinicians will be located out our new Joondalup clinic, which will be welcoming families in Term 4.